Western Blot (WB)
(CRFR1 Antibody (Q103) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the CRFR1 antibody detected the CRFR1 protein (arrow).)
Rabbit CRFR1 Polyclonal Antibody | anti-CRHR1 antibody
CRFR1 Antibody (Q103)
Western Blot (WB)
(CRFR1 Antibody (Q103) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the CRFR1 antibody detected the CRFR1 protein (arrow).)
Western Blot (WB)
(CRFR1 Antibody (Q103) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the CRFR1 antibody detected the CRFR1 protein (arrow).)
Flow Cytometry (FC/FACS)
(CRFR1 Antibody (Q103) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Flow Cytometry (FC/FACS)
(CRFR1 Antibody (Q103) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
neuropeptides of the corticotropin releasing hormone family that
are major regulators of the hypothalamic-pituitary-adrenal pathway.
The encoded protein is essential for the activation of signal
transduction pathways that regulate diverse physiological processes
including stress, reproduction, immune response and obesity.
Alternative splicing results in multiple transcript variants.
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)
Hillhouse, E.W., et al. Endocr. Rev. 27(3):260-286(2006)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Readthrough transcription also exists between this gene and upstream GeneID:401884 (ADP-ribosylation factor 3 pseudogene), and the readthrough transcripts encode isoforms that share similarity with the products of this gene. [provided by RefSeq, Dec 2014]
Uniprot Description
CRF-R1: a G-protein coupled receptor that specifically binds corticotropin-releasing hormone, a potent mediator of endocrine, autonomic, behavioral, and immune responses to stress. Four splice-variant isoforms have been described.
Protein type: GPCR, family 2; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 17q21.31
Cellular Component: multivesicular body; cell soma; apical part of cell; integral to plasma membrane; dendrite; integral to membrane; plasma membrane; trans-Golgi network; vesicle; intrinsic to plasma membrane
Molecular Function: protein binding; corticotropin-releasing hormone binding; corticotropin-releasing hormone receptor activity; protein complex binding; G-protein alpha-subunit binding; corticotrophin-releasing factor receptor activity
Biological Process: fear response; hypothalamus development; hormone-mediated signaling; adrenal gland development; adenylate cyclase activation; positive regulation of mast cell degranulation; female pregnancy; behavioral response to ethanol; memory; behavioral response to pain; general adaptation syndrome, behavioral process; elevation of cytosolic calcium ion concentration; epithelial cell differentiation; neuropeptide signaling pathway; adrenocorticotropin hormone secretion; behavioral response to cocaine; negative regulation of epinephrine secretion; response to hypoxia; visual learning; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); immune response; parturition; response to electrical stimulus
Research Articles on CRHR1
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Product Notes
The CRHR1 crhr1 (Catalog #AAA9200794) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 88-119. The CRFR1 Antibody (Q103) reacts with Human (Predicted Reactivity: Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's CRFR1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS). WB~~1:1000. Researchers should empirically determine the suitability of the CRHR1 crhr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CRFR1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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