Goat CREB3L2/BBF2H7 Polyclonal Antibody | anti-CREB3L2/BBF2H7 antibody

Anti-CREB3L2/BBF2H7 Antibody (aa15-28)

Cat. Num. AAA2400972

• Gene Names: CREB3L2; BBF2H7
• Reactivity: Human; Predicted: Guinea pig, Monkey
• Applications: ELISA, Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: CREB3L2/BBF2H7; Polyclonal Antibody; Anti-CREB3L2/BBF2H7 Antibody (aa15-28); Rabbit Polyclonal (IgG) to Human CREB3L2/BBF2H7; CREB3L2; Basic transcription factor 2; FUS/BBF2H7 protein; TCAG_1951439; B-ZIB transcription factor; BBF2H7; anti-CREB3L2/BBF2H7 antibody

• Host: Goat
• Reactivity: Human; Predicted: Guinea pig, Monkey
• Clonality: Polyclonal
• Specificity: Human CREB3L2/BBF2H7. This antibody is expected to recognize both reported isoforms (NP_919047.2; NP_001240704.1).
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Sequence Length: 520

• Applicable Applications for anti-CREB3L2/BBF2H7 antibody: ELISA (EIA), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
• Application Notes: ELISA: 1:128000; IHC-P: 5 ug/ml; WB: 1-3 ug/ml
• Immunogen: Synthetic peptide DRKLSELSEPGDGE-C from the N-terminus of human CREB3L2/BBF2H7 (NP_919047.2; NP_001240704.1). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Guinea pig (100%); Elephant (93%); Mouse, Rat, Ferret, Bovine, Panda, Rabbit, Horse (86%).
• Conjugation: Unconjugated
• Epitope: aa15-28
• Preparation and Storage: Store at -20 degree C.; Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Anti-CREB3L2/BBF2H7 antibody IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Western Blot (WB)

(CREB3L2 antibody (1 ug/ml) staining of Human Placenta lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)

Related Product Information for anti-CREB3L2/BBF2H7 antibody

Transcriptional activator which is processed and activated duringendoplasmic reticulum stress late phase. Binds to the cAMP responseelement (CRE) and activates transcription through CRE. Regulates the transcription of unfolded protein response target genes, preventingaccumulation of unfolded proteins in damaged neurons.

NCBI and Uniprot Product Information

• NCBI GI #: 56550067
• NCBI GeneID: 64764
• NCBI Accession #: NP_919047.2
• NCBI GenBank Nucleotide #: NM_194071.3
• UniProt Accession #: Q70SY1; Q6P454; Q6ZMR6
• Molecular Weight: 27,722 Da
• NCBI Official Full Name: cyclic AMP-responsive element-binding protein 3-like protein 2 isoform 1
• NCBI Official Synonym Full Names: cAMP responsive element binding protein 3 like 2
• NCBI Official Symbol: CREB3L2
• NCBI Official Synonym Symbols: BBF2H7
• NCBI Protein Information: cyclic AMP-responsive element-binding protein 3-like protein 2
• UniProt Protein Name: Cyclic AMP-responsive element-binding protein 3-like protein 2
• UniProt Gene Name: CREB3L2
• UniProt Synonym Gene Names: BBF2H7; cAMP-responsive element-binding protein 3-like protein 2

NCBI Description

This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Uniprot Description

Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (). In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827). In vitro activates transcription of target genes via direct binding to the CRE site (PubMed:17178827).