Cyclic AMP-responsive element-binding protein 3-like protein 2 (CREB3L2) Recombinant Protein | CREB3L2 recombinant protein

Recombinant Human Cyclic AMP-responsive element-binding protein 3-like protein 2 (CREB3L2)

Cat. Num. AAA1331584

• Gene Names: CREB3L2; BBF2H7
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Cyclic AMP-responsive element-binding protein 3-like protein 2 (CREB3L2); Recombinant Human Cyclic AMP-responsive element-binding protein 3-like protein 2 (CREB3L2); Cyclic AMP-responsive element-binding protein 3-like protein 2; cAMP-responsive element-binding protein 3-like protein 2; BBF2 human homolog on chromosome 7Cleaved into the following chain:; 1. Processed cyclic AMP-responsive element-binding protein 3-lik; CREB3L2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-247aa; Full Length of BC063666
• Sequence: MEVLESGEQGVLQWDRKLSELSEPGDGEALMYHTHFSELLDEFSQNVLGQLLNDPFLSEKSVSMEVEPSPTSPAPLIQAEHSYSLCEEPRAQSPFTHITSDSFNDDEVESEKWYLSTDFPSTSIKTEPVTDEPPPGLVPSVTLTITAISTPLEKEEPPLEMNTGVDSSCQTIIPKIKLEPHEVDQFLNFSPKEGLSALPVSLWVMDMVSGSTEREYGERAGMSLYHRCCSWLYEIALFLKNKNFASK
• Sequence Length: 379

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

SDS-PAGE

Related Product Information for CREB3L2 recombinant protein

Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes. In a neuroblastoma cell line, protects cells from ER stress-induced death. In vitro activates transcription of target genes via direct binding to the CRE site.

Product Categories/Family for CREB3L2 recombinant protein

Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 359339005
• NCBI GeneID: 64764
• NCBI Accession #: NP_001240704.1
• NCBI GenBank Nucleotide #: NM_001253775.1
• UniProt Accession #: Q70SY1; Q6P454; Q6ZMR6
• Molecular Weight: 54.6 kDa
• NCBI Official Full Name: cyclic AMP-responsive element-binding protein 3-like protein 2 isoform 2
• NCBI Official Synonym Full Names: cAMP responsive element binding protein 3-like 2
• NCBI Official Symbol: CREB3L2
• NCBI Official Synonym Symbols: BBF2H7
• NCBI Protein Information: cyclic AMP-responsive element-binding protein 3-like protein 2; TCAG_1951439; FUS/BBF2H7 protein; B-ZIB transcription factor; basic transcription factor 2; BBF2 human homolog on chromosome 7; cAMP-responsive element-binding protein 3-like protein 2
• UniProt Protein Name: Cyclic AMP-responsive element-binding protein 3-like protein 2
• Protein Family: Cyclic AMP-responsive element-binding protein 3-like protein
• UniProt Gene Name: CREB3L2
• UniProt Synonym Gene Names: BBF2H7; cAMP-responsive element-binding protein 3-like protein 2
• UniProt Entry Name: CR3L2_HUMAN

NCBI Description

This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Uniprot Description

CREB3L2: Transcriptional activator which is processed and activated during endoplasmic reticulum stress late phase. Binds to the cAMP response element (CRE) and activates transcription through CRE. Regulates the transcription of unfolded protein response target genes, preventing accumulation of unfolded proteins in damaged neurons. Also regulates the expression of SEC23A, accelerating protein trafficking from the ER to the Golgi thereby playing a key role in chondrocyte differentiation and formation of epiphyseal cartilage. A chromosomal aberration involving CREB3L2 is found in low grade fibromyxoid sarcoma (LGFMS). Translocation t(7;16)(q33;p11) with FUS. Belongs to the bZIP family. ATF subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; Membrane protein, integral; Oncoprotein

Chromosomal Location of Human Ortholog: 7q34

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane; nucleus

Biological Process: ER to Golgi vesicle-mediated transport; transcription, DNA-dependent; unfolded protein response; positive regulation of transcription, DNA-dependent; cartilage development; chondrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter