Rabbit CREB1, p43 Polyclonal Antibody | anti-CREB1 antibody

CREB1, p43 (cAMP Response Element Binding Protein)

Cat. Num. AAA614531

• Gene Names: CREB1; CREB; MGC9284
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunoprecipitation
• Purity: Purified; Purified Ig
• Synonyms: CREB1; p43; Polyclonal Antibody; p43 (cAMP Response Element Binding Protein); Anti -CREB1; anti-CREB1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human cyclic AMP responsive element binding protein-1 (CREB-1, p43). By Western blot it shows a major band at 46kD when assayed against a lysate of 1x10e6 Raji B cells. Minor bands at 75kD and 43kD may be noted. Partial reactivity to CREM-1 protein. May react non-specifically with other proteins. Species Crossreactivity: Human, rat, mouse.
• Purity/Purification: Purified; Purified Ig
• Form/Format: Supplied as a sterile filtered liquid in 0.01M Sodium Phosphate buffer, pH 7.4 containing 0.15 M Sodium Chloride with 0.01% sodium azide.

• Applicable Applications for anti-CREB1 antibody: ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP)
• Application Notes: Western blot: 1:500-1:1,000 Immunoprecipitation EIA Supershift assay: 0.5-1.0ml per assay.
• Immunogen: CREB-1 (p43) peptide corresponding to the N-terminal (aa 5-45) of human protein conjugated to KLH.
• Preparation and Storage: Maintain frozen at-20 degree C in undiluted aliquots for up to six months. Avoid repeated freeze/thaw cycles.

Product Categories/Family for anti-CREB1 antibody

Antibodies; Abs to Transcription Factors

NCBI and Uniprot Product Information

• NCBI GI #: 19745184
• NCBI GeneID: 1385
• NCBI Accession #: NP_604391.1
• NCBI GenBank Nucleotide #: NM_134442.3
• UniProt Accession #: P16220; P21934; Q9UMA7; Q16366; Q16367; Q4ZG78; Q53RU9; Q53X93; Q5U0J5; Q6V963
• Molecular Weight: 36,688 Da
• NCBI Official Full Name: cyclic AMP-responsive element-binding protein 1 isoform B
• NCBI Official Synonym Full Names: cAMP responsive element binding protein 1
• NCBI Official Symbol: CREB1
• NCBI Official Synonym Symbols: CREB; MGC9284
• NCBI Protein Information: cyclic AMP-responsive element-binding protein 1; CREB-1; OTTHUMP00000163864; OTTHUMP00000163865; OTTHUMP00000206660; OTTHUMP00000206662; OTTHUMP00000206667; transactivator protein; active transcription factor CREB; cAMP-response element-binding protein-1; cAMP-responsive element-binding protein 1
• UniProt Protein Name: Cyclic AMP-responsive element-binding protein 1
• Protein Family: Cyclic AMP-responsive element-binding protein
• UniProt Gene Name: CREB1
• UniProt Entry Name: CREB1_HUMAN

NCBI Description

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq]

Uniprot Description

CREB: a transcription factor of the leucine zipper family of DNA binding proteins. Binds as a homodimer to the cAMP-responsive element (CRE). Phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Two splice-variant isoforms have been described.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 2q34

Cellular Component: nucleoplasm; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; enzyme binding; transcription cofactor activity; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; lactation; circadian rhythm; axon guidance; response to glucagon stimulus; viral reproduction; nerve growth factor receptor signaling pathway; positive regulation of osteoclast differentiation; positive regulation of transcription, DNA-dependent; stress-activated MAPK cascade; positive regulation of multicellular organism growth; toll-like receptor 3 signaling pathway; signal transduction; protein amino acid phosphorylation; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; response to organic substance; synaptic transmission; toll-like receptor 4 signaling pathway; response to drug; epidermal growth factor receptor signaling pathway; mitochondrion organization and biogenesis; Notch signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; protein stabilization; secretory granule organization and biogenesis; MyD88-independent toll-like receptor signaling pathway; organelle organization and biogenesis; positive regulation of hormone secretion; positive regulation of lipid biosynthetic process; memory; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; phospholipase C activation; pituitary gland development; toll-like receptor signaling pathway; positive regulation of fat cell differentiation; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; regulation of cell size

Disease: Histiocytoma, Angiomatoid Fibrous