Rabbit anti-Human CQ068 Polyclonal Antibody | anti-CQ068 antibody

CQ068, ID (CTC1, C17orf68, CST complex subunit CTC1, Conserved telomere maintenance component 1, HBV DNAPTP1-transactivated protein B) (AP)

Cat. Num. AAA6288538

• Gene Names: CTC1; CRMCC; AAF132; AAF-132; C17orf68; tmp494178
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: CQ068; Polyclonal Antibody; ID (CTC1; C17orf68; CST complex subunit CTC1; Conserved telomere maintenance component 1; HBV DNAPTP1-transactivated protein B) (AP); CTC1; HBV DNAPTP1-transactivated protein B; anti-CQ068 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-CQ068 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: CQ068 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 774~803 amino acids from the Central region of human CQ068.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western blot analysis of CQ068 Antibody (Center) in K562 cell line lysates (35ug/lane). CQ068 (arrow) was detected using the purified Pab.)

Flow Cytometry (FC/FACS)

(CQ068 Antibody (Center) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)

Related Product Information for anti-CQ068 antibody

CQ068 is subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication. CQ068 also appears to function in a telomere-associated complex with OBFC1 and TEN1.

Product Categories/Family for anti-CQ068 antibody

Antibodies; KIAA; orf

References

Surovtseva, Y.V., et al. Mol. Cell 36(2):207-218(2009). Miyake, Y., et al. Mol. Cell 36(2):193-206(2009). Casteel, D.E., et al. J. Biol. Chem. 284(9):5807-5818(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 292495002
• NCBI GeneID: 80169
• UniProt Accession #: Q2NKJ3; Q1PCD1; Q2TBE3; Q8N3S6; Q9H6L0; B3KR66; C9JEX5
• Molecular Weight: 114,142 Da
• NCBI Official Full Name: CST complex subunit CTC1
• NCBI Official Synonym Full Names: CTS telomere maintenance complex component 1
• NCBI Official Symbol: CTC1
• NCBI Official Synonym Symbols: CRMCC; AAF132; AAF-132; C17orf68; tmp494178
• NCBI Protein Information: CST complex subunit CTC1
• UniProt Protein Name: CST complex subunit CTC1
• UniProt Gene Name: CTC1
• UniProt Synonym Gene Names: C17orf68
• UniProt Entry Name: CTC1_HUMAN

NCBI Description

This gene encodes a component of the CST complex. This complex plays an essential role in protecting telomeres from degradation. This protein also forms a heterodimer with the CST complex subunit STN1 to form the enzyme alpha accessory factor. This enzyme regulates DNA replication. Mutations in this gene are the cause of cerebroretinal microangiopathy with calcifications and cysts. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012]

Uniprot Description

CTC1: Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites. Defects in CTC1 are the cause of cerebroretinal microangiopathy with calcifications and cysts (CRMCC). An autosomal recessive pleiomorphic disorder characterized primarily by intracranial calcifications, leukodystrophy, and brain cysts. Affected individuals manifest a phenotype consistent with Coats plus syndrome or Labrune syndrome. Coats plus syndrome patients have retinal telangiectasia and exudates as well as extraneurologic manifestations, including osteopenia with poor bone healing and a high risk of gastrointestinal bleeding and portal hypertension caused by vasculature ectasias in the stomach, small intestine, and liver. Some individuals with Coats syndrome also have hair, skin, and nail changes, as well as anemia. Patients with Labrune syndrome do not have extraneurologic manifestations. Belongs to the CTC1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA replication; DNA-binding

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: nuclear chromosome, telomeric region; nucleus

Molecular Function: protein binding; single-stranded DNA binding; telomeric DNA binding

Biological Process: bone marrow development; multicellular organism growth; negative regulation of telomerase activity; positive regulation of DNA replication; positive regulation of fibroblast proliferation; regulation of G2/M transition of mitotic cell cycle; response to DNA damage stimulus; spleen development; telomere maintenance; thymus development

Disease: Cerebroretinal Microangiopathy With Calcifications And Cysts