Rabbit CPEB1 Polyclonal Antibody | anti-CPEB1 antibody

CPEB1 Antibody

Cat. Num. AAA150196

• Gene Names: CPEB1; CPEB; CPEB-1; CPE-BP1; hCPEB-1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: CPEB1 Antibody is affinity chromatography purified via peptide column.
• Synonyms: CPEB1; Polyclonal Antibody; CPEB1 Antibody; CEBP; CPEB; CPEB-1; CPE-BP1; hCPEB-1; Cytoplasmic polyadenylation element-binding protein 1; cytoplasmic polyadenylation element binding protein 1; anti-CPEB1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: CPEB1 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid; CPEB1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 566

• Applicable Applications for anti-CPEB1 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: CPEB1 antibody can be used for detection of CPEB1 by Western blot at 1 - 2 mug/mL.; Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
• Conjugate: Unconjugated
• Immunogen: CPEB1 antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human CPEB1. The immunogen is located within amino acids 50-100 of CPEB1.
• Positive Control: MBS151758 - Rat Brain Tissue Lysate
• Preparation and Storage: CPEB1 antibody can be stored at 4°C for three months and -204°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of CPEB1 in rat brain tissue lysate with CPEB1 antibody at (A) 1 and (B) 2 μg/mL.)

Related Product Information for anti-CPEB1 antibody

CPEB1 Antibody: CPEB1 is an RNA binding protein that contains an RNA-recognition motif and a zinc finger-containing region found in a wide range of vertebrates and invertebrates. CPEB1 forms the nucleus of a complex of factors that regulate poly(A) elongation and promotes polyadenylation-induced translation. CPEB1 mediates many diverse biological processes such as germ cell development, cell division and senescence, and synaptic plasticity. Recently, it was discovered that CPEB1 is involved in beta-catenin mRNA translation and cell migration in astrocytes as well as regulating hypoxia-inducible factor (HIF)-1 expression, demonstrating the wide range of processes in which CPEB1 plays a role. At least four isoforms of CPEB1 are known to exist.

NCBI and Uniprot Product Information

• NCBI GI #: 74762720
• NCBI GeneID: 64506
• UniProt Accession #: Q9BZB8; Q86W46; Q8IV41; Q9BZB7; Q9H8V5; B7Z6C6
• NCBI Official Full Name: Cytoplasmic polyadenylation element-binding protein 1
• NCBI Official Synonym Full Names: cytoplasmic polyadenylation element binding protein 1
• NCBI Official Symbol: CPEB1
• NCBI Official Synonym Symbols: CPEB; CPEB-1; CPE-BP1; hCPEB-1
• NCBI Protein Information: cytoplasmic polyadenylation element-binding protein 1; CPE-binding protein 1
• UniProt Protein Name: Cytoplasmic polyadenylation element-binding protein 1
• UniProt Gene Name: CPEB1
• UniProt Synonym Gene Names: CPEB; CPE-BP1; CPE-binding protein 1; h-CEBP; hCPEB-1
• UniProt Entry Name: CPEB1_HUMAN

NCBI Description

This gene encodes a member of the cytoplasmic polyadenylation element binding protein family. This highly conserved protein binds to a specific RNA sequence, called the cytoplasmic polyadenylation element, found in the 3' untranslated region of some mRNAs. The encoded protein functions in both the cytoplasm and the nucleus. It is involved in the regulation of mRNA translation, as well as processing of the 3' untranslated region, and may play a role in cell proliferation and tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Uniprot Description

CPEB: cytoplasmic polyadenylation element binding protein 1. Binds to the protein CPE and drives its polyadenylation. Activated by the protein kinase AurA. Insulin and progesterone stimulate AurA-catalyzed phosphorylation of CPEB in oocytes. Neuronal CPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in aplysia.

Protein type: Translation; RNA-binding

Chromosomal Location of Human Ortholog: 15q25.2

Cellular Component: postsynaptic membrane; dendrite; postsynaptic density; cytoplasm; nucleus; cell junction

Molecular Function: metal ion binding; translation repressor activity, nucleic acid binding; nucleotide binding

Biological Process: synaptonemal complex assembly; cellular response to insulin stimulus; mRNA processing; regulation of neuronal synaptic plasticity