Rabbit COX8A Polyclonal Antibody | anti-COX8A antibody

COX8A Polyclonal Antibody

Cat. Num. AAA2528199

• Gene Names: COX8A; COX; COX8; VIII; COX8L; COX8-2; VIII-L
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: COX8A; Polyclonal Antibody; COX8A Polyclonal Antibody; COX; COX8; VIII; COX8L; COX8-2; VIII-L; anti-COX8A antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 0.5mg/mL (varies by lot)
• Sequence Length: 69

• Applicable Applications for anti-COX8A antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:10-1:50
• Immunogen: Recombinant protein of human COX8A
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human colon cancer tissue using COX8A Polyclonal Antibody at dilution of 1:12)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human gastric cancer tissue using COX8A Polyclonal Antibody at dilution of 1:12)

Related Product Information for anti-COX8A antibody

The protein encoded by this gene is the terminal enzyme of the respiratory chain, coupling the transfer of electrons from cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical gradient across the inner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which perform the catalytic function, the eukaryotic enzyme contains nuclear-encoded smaller subunits, ranging in number from 4 in some organisms to 10 in mammals. It has been proposed that nuclear-encoded subunits may be involved in the modulation of the catalytic function. This gene encodes one of the nuclear-encoded subunits.

NCBI and Uniprot Product Information

• NCBI GI #: 117132
• NCBI GeneID: 1351
• Molecular Weight: 7,579 Da
• NCBI Official Full Name: Cytochrome c oxidase subunit 8A, mitochondrial
• NCBI Official Synonym Full Names: cytochrome c oxidase subunit VIIIA (ubiquitous)
• NCBI Official Symbol: COX8A
• NCBI Official Synonym Symbols: COX; COX8; VIII; COX8L; COX8-2; VIII-L
• NCBI Protein Information: cytochrome c oxidase subunit 8A, mitochondrial; cytochrome c oxidase polypeptide VIII-liver/heart; cytochrome c oxidase subunit 8-2; cytochrome c oxidase subunit 8A (ubiquitous); cytochrome c oxidase subunit VIII
• UniProt Protein Name: Cytochrome c oxidase subunit 8A, mitochondrial
• UniProt Gene Name: COX8A
• UniProt Synonym Gene Names: COX8; COX8L
• UniProt Entry Name: COX8A_HUMAN

NCBI Description

The protein encoded by this gene is the terminal enzyme of the respiratory chain, coupling the transfer of electrons from cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical gradient across the inner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which perform the catalytic function, the eukaryotic enzyme contains nuclear-encoded smaller subunits, ranging in number from 4 in some organisms to 10 in mammals. It has been proposed that nuclear-encoded subunits may be involved in the modulation of the catalytic function. This gene encodes one of the nuclear-encoded subunits. [provided by RefSeq, Jul 2008]

Uniprot Description

COX8A: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Belongs to the cytochrome c oxidase VIII family.

Protein type: Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Mitochondrial

Chromosomal Location of Human Ortholog: 11q12-q13

Cellular Component: mitochondrial inner membrane; integral to membrane

Molecular Function: cytochrome-c oxidase activity

Biological Process: cellular metabolic process; generation of precursor metabolites and energy; transmembrane transport