Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using MSH3 antibody.)
Rabbit anti-Human MSH3 Polyclonal Antibody | anti-MSH3 antibody
MSH3 (MutS Homolog 3, DUP, MRP1) (PE)
WB: 1:500-1:2000
Applications are based on unconjugated antibody.
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using MSH3 antibody.)
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using MSH3 antibody.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011]
Uniprot Description
MSH3: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion- deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Defects in MSH3 are a cause of susceptibility to endometrial cancer (ENDMC). Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.
Protein type: DNA repair, damage
Chromosomal Location of Human Ortholog: 5q11-q12
Cellular Component: nucleoplasm; nuclear chromosome; membrane; nucleus; MutSbeta complex
Molecular Function: DNA-dependent ATPase activity; double-strand/single-strand DNA junction binding; protein homodimerization activity; dinucleotide repeat insertion binding; oxidized purine DNA binding; mismatched DNA binding; loop DNA binding; Y-form DNA binding; centromeric DNA binding; protein binding; enzyme binding; single guanine insertion binding; guanine/thymine mispair binding; dinucleotide insertion or deletion binding; ATP binding; single-stranded DNA binding
Biological Process: positive regulation of helicase activity; negative regulation of DNA recombination; mismatch repair; meiotic recombination; somatic recombination of immunoglobulin gene segments; DNA repair; maintenance of DNA repeat elements; meiotic mismatch repair
Disease: Endometrial Cancer
Research Articles on MSH3
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Product Notes
The MSH3 msh3 (Catalog #AAA6427485) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MSH3 (MutS Homolog 3, DUP, MRP1) (PE) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MSH3 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Western Blot (WB). IHC: 1:50-1:200 WB: 1:500-1:2000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the MSH3 msh3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MSH3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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