Knockout Validation
(Knockout Validation: Lane 1: Wild-type A375 cell lysate; Lane 2: CBG knockout A375 cell lysate; Predicted MW: 45kd Observed MW: 45kd Primary Ab: 1ug/ml Rabbit Anti-Human CBG Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
Rabbit anti-Human Corticosteroid Binding Globulin (CBG) Polyclonal Antibody | anti-CBG antibody
Cy3-Linked Polyclonal Antibody to Corticosteroid Binding Globulin (CBG)
Knockout Validation
(Knockout Validation: Lane 1: Wild-type A375 cell lysate; Lane 2: CBG knockout A375 cell lysate; Predicted MW: 45kd Observed MW: 45kd Primary Ab: 1ug/ml Rabbit Anti-Human CBG Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
Knockout Validation
(Knockout Validation: Lane 1: Wild-type A375 cell lysate; Lane 2: CBG knockout A375 cell lysate; Predicted MW: 45kd Observed MW: 45kd Primary Ab: 1ug/ml Rabbit Anti-Human CBG Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. [provided by RefSeq, Jul 2008]
Uniprot Description
SERPINA6: Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species. Defects in SERPINA6 are a cause of corticosteroid-binding globulin deficiency (CBG deficiency). CBG deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue. Belongs to the serpin family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 14q32.13
Cellular Component: extracellular space
Molecular Function: serine-type endopeptidase inhibitor activity; steroid binding
Disease: Corticosteroid-binding Globulin Deficiency
Research Articles on CBG
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Product Notes
The CBG serpina6 (Catalog #AAA2052750) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Cy3-Linked Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Corticosteroid Binding Globulin (CBG) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA). Researchers should empirically determine the suitability of the CBG serpina6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Corticosteroid Binding Globulin (CBG), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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