Western Blot (WB)
(COPS8 Antibody (N-term) western blot analysis in Ramos cell line lysates (35ug/lane).This demonstrates the COPS8 antibody detected the COPS8 protein (arrow).)
Rabbit anti-Human COPS8 Polyclonal Antibody | anti-COPS8 antibody
COPS8, NT (COPS8, CSN8, COP9 signalosome complex subunit 8, COP9 homolog, JAB1-containing signalosome subunit 8)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Western Blot (WB)
(COPS8 Antibody (N-term) western blot analysis in Ramos cell line lysates (35ug/lane).This demonstrates the COPS8 antibody detected the COPS8 protein (arrow).)
Western Blot (WB)
(COPS8 Antibody (N-term) western blot analysis in Ramos cell line lysates (35ug/lane).This demonstrates the COPS8 antibody detected the COPS8 protein (arrow).)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Uniprot Description
COPS8: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Belongs to the CSN8 family. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 2q37.3
Cellular Component: signalosome; nucleoplasm; perinuclear region of cytoplasm; cytoplasm; nucleus
Biological Process: negative regulation of cell proliferation; cullin deneddylation; activation of NF-kappaB-inducing kinase
Research Articles on COPS8
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Product Notes
The COPS8 cops8 (Catalog #AAA6008487) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The COPS8, NT (COPS8, CSN8, COP9 signalosome complex subunit 8, COP9 homolog, JAB1-containing signalosome subunit 8) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's COPS8 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in Western Blot, ELISA Dilution: ELISA: 1:1,000 Western Blot: 1:100-500. Researchers should empirically determine the suitability of the COPS8 cops8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "COPS8, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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