Rabbit anti-Human COPS7A Polyclonal Antibody | anti-COPS7A antibody

COPS7A, CT (COPS7A, CSN7A, DERP10, COP9 signalosome complex subunit 7a, Dermal papilla-derived protein 10, JAB1-containing signalosome subunit 7a) (FITC)

Cat. Num. AAA6287892

• Gene Names: COPS7A; CSN7; CSN7A; SGN7a
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: COPS7A; Polyclonal Antibody; CT (COPS7A; CSN7A; DERP10; COP9 signalosome complex subunit 7a; Dermal papilla-derived protein 10; JAB1-containing signalosome subunit 7a) (FITC); JAB1-containing signalosome subunit 7a; anti-COPS7A antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
• Sequence Length: 275

• Applicable Applications for anti-COPS7A antibody: Immunohistochemistry (IHC), FLISA, Western Blot (WB)
• Application Notes: IHC: 1:10-50; FLISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: COPS7A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 244-274 amino acids from the C-terminal region of human COPS7A.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(COPS7A Antibody (C-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the COPS7A antibody detected the COPS7A protein (arrow).)

Immunohistochemistry (IHC)

(COPS7A Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of COPS7A Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Related Product Information for anti-COPS7A antibody

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Product Categories/Family for anti-COPS7A antibody

Antibodies; Signal Transduction

References

Matsuoka, S., et al. Science 316(5828):1160-1166(2007). Stelzl, U., et al. Cell 122(6):957-968(2005). Obuse, C., et al. Nat. Cell Biol. 6(11):1135-1141(2004). Wolf, D.A., et al. Nat. Cell Biol. 5(12):1029-1033(2003). Groisman, R., et al. Cell 113(3):357-367(2003).

NCBI and Uniprot Product Information

• NCBI GI #: 7705330
• NCBI GeneID: 50813
• NCBI Accession #: NP_057403.1
• NCBI GenBank Nucleotide #: NP_057403.1
• UniProt Accession #: Q9UBW8
• NCBI Official Full Name: COP9 signalosome complex subunit 7a
• NCBI Official Synonym Full Names: COP9 signalosome subunit 7A
• NCBI Official Symbol: COPS7A
• NCBI Official Synonym Symbols: CSN7; CSN7A; SGN7a
• NCBI Protein Information: COP9 signalosome complex subunit 7a
• UniProt Protein Name: COP9 signalosome complex subunit 7a
• UniProt Gene Name: COPS7A
• UniProt Synonym Gene Names: CSN7A; DERP10; SGN7a; Signalosome subunit 7a

NCBI Description

This gene encodes a component of the COP9 signalosome, an evolutionarily conserved multi-subunit protease that regulates the activity of the ubiquitin conjugation pathway. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Mar 2014]

Uniprot Description

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.