Rabbit COPS4 Polyclonal Antibody | anti-COPS4 antibody

COPS4 Rabbit Polyclonal

Cat. Num. AAA768104

• Gene Names: COPS4; CSN4
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: COPS4; Polyclonal Antibody; COPS4 Rabbit Polyclonal; anti-COPS4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 420

• Applicable Applications for anti-COPS4 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
• Immunogen: COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human pancreas tissue slide using MBS768104 (COPS4 Antibody) at dilution of 1:50)

Testing Data

()

Western Blot (WB)

(A2780 cells were subjected to SDS PAGE followed by western blot with MBS768104 (COPS4 antibody) at dilution of 1:500)

NCBI and Uniprot Product Information

• NCBI GI #: 957951111
• NCBI GeneID: 51138
• Molecular Weight: 40,197 Da
• NCBI Official Full Name: COP9 constitutive photomorphogenic-like protein subunit 4 isoform 2
• NCBI Official Synonym Full Names: COP9 signalosome subunit 4
• NCBI Official Symbol: COPS4
• NCBI Official Synonym Symbols: CSN4
• NCBI Protein Information: COP9 signalosome complex subunit 4
• UniProt Protein Name: COP9 signalosome complex subunit 4
• UniProt Gene Name: COPS4
• UniProt Synonym Gene Names: CSN4; SGN4; Signalosome subunit 4
• UniProt Entry Name: CSN4_HUMAN

NCBI Description

This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Uniprot Description

COPS4: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Belongs to the CSN4 family.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 4q21.22

Cellular Component: cell junction; cytosol; nucleoplasm; nucleus; signalosome; synaptic vesicle

Molecular Function: NEDD8-specific protease activity; protein binding

Biological Process: cullin deneddylation; nucleotide-excision repair, DNA damage recognition; protein deneddylation; transcription-coupled nucleotide-excision repair