Rabbit anti-Rat Contactin 6 Polyclonal Antibody | anti-CNTN6 antibody
Contactin 6 (Neural recognition molecule NB-3, hNB-3, Contactin-6 precursor, MGC133256, NB3, NB-3)
Gene Names
CNTN6; NB3; MGC133256
Reactivity
Rat
Applications
Immunohistochemistry
Purity
SerumSerum
Synonyms
Contactin 6; Polyclonal Antibody; Contactin 6 (Neural recognition molecule NB-3; hNB-3; Contactin-6 precursor; MGC133256; NB3; NB-3); Anti -Contactin 6 (Neural recognition molecule NB-3; anti-CNTN6 antibody
Host
Rabbit
Reactivity
Rat
Clonality
Polyclonal
Specificity
Stains the NB3 in DRG, where it nicely stains a subpopulation of neurons and in the trigeminal nerve root, where staining is restricted to the oligodendrocytes. Species Crossreactivity: Confirmed to react with rat Contactin-6
Purity/Purification
Serum
Serum
Serum
Form/Format
Supplied as a lyophilized powder. Reconstitute in 100ul of sterile water. Centrifuge to remove any insoluble material.
Applicable Applications for anti-CNTN6 antibody
Immunohistochemistry (IHC)
Application Notes
Suitable for use in Immunohistochemistry.
Dilution: Immunohistochemistry: 1:1000-1:5000
Dilution: Immunohistochemistry: 1:1000-1:5000
Immunogen
A synthetic peptide (KLH-KMSSLSSVGVQILKPSTQF) as part of rat contactin-6.
Cellular Localization
Cell membrane; lipid-anchor; GPI-anchor.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-CNTN6 antibody
The neural adhesion molecule Contactin-6, also known as NB-3, is a contactin/F3 subgroup member of immunoglobulin superfamily. It is expressed exclusively in the nervous system and mainly upregulated at the early postnatal stage during mouse brain development. Employing Northern blot analysis Kamei et al found that amongst different regions of the adult human nervous system cerebellum expressed highest level of NB-3 mRNA. The expression of NB-3 in the cerebellum increases until adulthood. In contrast, the expression in the cerebrum declines to a low level after postnatal day 7. NB-3 like other neural recognition molecules plays a vitally important role in axonal guidance during development, plasticity, and maintenance of synaptic connections in the adult brain. Cui et al recently showed that NB-3 acts as a novel Notch ligand to participate in oligodendrocyte generation. Furthermore, NB-3 triggers nuclear translocation of the Notch intracellular domain and promotes oligodendrogliogenesis from progenitor cells and differentiation of oligodendrocyte precursor cells via Deltex1. In primary oligodendrocytes, NB-3 increases myelin-associated glycoprotein transcripts. Hence, the NB-3/Notch signaling pathway may be worthwhile a closer examination for its potential for the treatment of demyelinating diseases. Human NB-3 shares with rat NB-3 86% identity in nucleotide sequences and 90% identity in amino acid sequences. Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination.
Product Categories/Family for anti-CNTN6 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
113,956 Da
NCBI Official Full Name
contactin-6
NCBI Official Synonym Full Names
contactin 6
NCBI Official Symbol
CNTN6
NCBI Official Synonym Symbols
NB3; MGC133256
NCBI Protein Information
contactin-6; OTTHUMP00000147565; OTTHUMP00000206867; neural adhesion molecule; neural recognition molecule NB-3
UniProt Protein Name
Contactin-6
Protein Family
UniProt Gene Name
CNTN6
UniProt Entry Name
CNTN6_HUMAN
NCBI Description
The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. [provided by RefSeq]
Uniprot Description
CNTN6: Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination. Belongs to the immunoglobulin superfamily. Contactin family.
Protein type: Membrane protein, GPI anchor; Cell adhesion; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3p26.3
Cellular Component: plasma membrane
Biological Process: axon guidance; Notch signaling pathway; central nervous system development; cell adhesion
Research Articles on CNTN6
1. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
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Product Notes
The CNTN6 cntn6 (Catalog #AAA614164) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Contactin 6 (Neural recognition molecule NB-3, hNB-3, Contactin-6 precursor, MGC133256, NB3, NB-3) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Contactin 6 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Suitable for use in Immunohistochemistry. Dilution: Immunohistochemistry: 1:1000-1:5000. Researchers should empirically determine the suitability of the CNTN6 cntn6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Contactin 6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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