CNTN6 recombinant protein

CNTN6 Protein, Human, Recombinant (hFc Tag)

Cat. Num. AAA8122124

• Gene Names: CNTN6; NB3
• Purity: >95% as determined by SDS-PAGE
• Synonyms: CNTN6; CNTN6 Protein; Human; Recombinant (hFc Tag); Human CNTN6 Protein (Fc Tag); contactin 6 Protein; NB3 Protein; contactin 6; CNTN6 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Ser999

• Species: Human
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: Asp 20
• Tag: C-human IgG1-Fc
• Protein Construction: A DNA sequence encoding the human CNTN6 (NP_055276.1)(Met1-Ser999) was expressed with the Fc region of human IgG1 at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for CNTN6 recombinant protein

Background: Copy number variations (CNVs) of the human CNTN6 gene caused by megabase-scale microdeletions or microduplications in the 3p26.3 region are often the cause of neurodevelopmental disorders, including intellectual disability and developmental delay. Contactin genes CNTN5 and CNTN6 code for neuronal cell adhesion molecules that promote neurite outgrowth in sensory-motor neuronal pathways. The deletion or duplication of the CNTN6 gene is associated with a wide spectrum of neurodevelopmental behavioral disorders. The protein encoded by CNTN6 is a member of the immunoglobulin superfamily and functions as a cell adhesion molecule that is involved in the formation of axon connections in the developing nervous system.

NCBI and Uniprot Product Information

• NCBI GI #: 7657361
• NCBI GeneID: 27255
• NCBI Accession #: NP_055276.1
• NCBI GenBank Nucleotide #: NM_014461.2
• UniProt Accession #: Q9UQ52; Q2KHM2
• Molecular Weight: 113,956 Da
• NCBI Official Full Name: contactin-6
• NCBI Official Synonym Full Names: contactin 6
• NCBI Official Symbol: CNTN6
• NCBI Official Synonym Symbols: NB3
• NCBI Protein Information: contactin-6; neural adhesion molecule; neural recognition molecule NB-3
• UniProt Protein Name: Contactin-6
• Protein Family: Contactin
• UniProt Gene Name: CNTN6
• UniProt Synonym Gene Names: hNB-3
• UniProt Entry Name: CNTN6_HUMAN

NCBI Description

The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. [provided by RefSeq, Jul 2008]

Uniprot Description

CNTN6: Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination. Belongs to the immunoglobulin superfamily. Contactin family.

Protein type: Membrane protein, GPI anchor; Cell adhesion; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3p26.3

Cellular Component: plasma membrane

Biological Process: axon guidance; Notch signaling pathway; central nervous system development; cell adhesion