Rabbit anti-Mouse Connexin 37 Polyclonal Antibody | anti-GJA4 antibody
Connexin 37 (CX37, Gap Junction Alpha 4 Protein, CXA-4)
Gene Names
GJA4; CX37
Reactivity
Mouse
Applications
ELISA, Western Blot
Purity
SerumSerum
Synonyms
Connexin 37; Polyclonal Antibody; Connexin 37 (CX37; Gap Junction Alpha 4 Protein; CXA-4); Anti -Connexin 37 (CX37; anti-GJA4 antibody
Host
Rabbit
Reactivity
Mouse
Clonality
Polyclonal
Isotype
IgG
Specificity
Mouse immunogenic peptide sequence is specific for Cx37. No significant homology is seen with other Connexin. Species Sequence Homology: 93% and 87% sequence homology with the rat and human Cx37, respectively (3). The mouse peptide sequence also shows substantial homology (68%) with Xenopus Cx41 protein.
Purity/Purification
Serum
Serum
Serum
Form/Format
Supplied as a liquid, 0.05% sodium azide, 40% glycerol.
Applicable Applications for anti-GJA4 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes
Suitable for use in ELISA, Western Blot.
Dilution: Western Blot: 1:1000-1:5000
ELISA: 1:100K using 50-100ng control peptide/well.
Dilution: Western Blot: 1:1000-1:5000
ELISA: 1:100K using 50-100ng control peptide/well.
Immunogen
A 16 amino acid peptide sequence within the C-terminal cytoplasmic domain of mouse Cx37 (2) was coupled to KLH (carrier protein) via the N-terminal Cysteine
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-GJA4 antibody
Gap junctions are composed of transmembrane channels that link the cytoplasm of neighboring cells. They differ from other membrane channels since they exist between two cells. Gap junctions are relatively non-specific and allow passive diffusion of small molecules up to 1000 Dalton. The junctions exist in almost all vertebrate and non-vertebrates cells. It is believed that gap junction play an important for intercellular communications and affect growth and differentiation of cells. Absence of intercellular communication mediated by gap junction may lead to transformed or cancerous growth. Gap junctional channel is composed of a hemichannel (connexon) in the cell membrane of one cell joined in mirror symmetry with a connexon in the opposing cell. Each connexon is an oligomer of six protein subunits that define the axial aqueous pore. Molecular cloning studies have identified a family of at least 12 highly related Connexins that are designated according to mol. wt, Cx26-50. Hydropathy analyses of Cx sequences predicts 4 transmembrane domains, 2 extracellular (EC), and 3 cytoplasmic (CP) domains. The EC, TM, and N-terminal CP domains are well conserved among family members, while Central and C-terminal domains are highly variable in both sequence and size. The N and C-termini are predicted to be cytoplasmic.
Product Categories/Family for anti-GJA4 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
37,414 Da
NCBI Official Full Name
connexin 37
NCBI Official Synonym Full Names
gap junction protein, alpha 4, 37kDa
NCBI Official Symbol
GJA4
NCBI Official Synonym Symbols
CX37
NCBI Protein Information
gap junction alpha-4 protein; connexin 37; connexin-37; OTTHUMP00000004181; OTTHUMP00000004182
UniProt Protein Name
Gap junction alpha-4 protein
Protein Family
UniProt Gene Name
GJA4
UniProt Entry Name
CXA4_HUMAN
NCBI Description
This gene encodes a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene have been associated with atherosclerosis and a higher risk of myocardial infarction. [provided by RefSeq]
Uniprot Description
GJA4: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Belongs to the connexin family. Alpha-type (group II) subfamily.
Protein type: Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 1p35.1
Cellular Component: connexon complex; integral to plasma membrane; gap junction
Molecular Function: protein binding
Biological Process: blood vessel development; intercellular junction assembly; cell-cell signaling; transport; calcium ion transport; response to pain
Research Articles on GJA4
Similar Products
Product Notes
The GJA4 gja4 (Catalog #AAA613064) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Connexin 37 (CX37, Gap Junction Alpha 4 Protein, CXA-4) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Connexin 37 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in ELISA, Western Blot. Dilution: Western Blot: 1:1000-1:5000 ELISA: 1:100K using 50-100ng control peptide/well. Researchers should empirically determine the suitability of the GJA4 gja4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Connexin 37, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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