Goat anti-Human Connexin 30, GJB6, Gap Junction Protein, beta 6, Polyclonal Antibody | anti-GJB6 antibody

Connexin 30, GJB6, Gap Junction Protein, beta 6, (30kDa)

Cat. Num. AAA630396

• Gene Names: GJB6; ED2; EDH; HED; CX30; DFNA3; DFNA3B; DFNB1B
• Reactivity: Human
• Applications: ELISA
• Purity: Affinity Purified; Purified by peptide affinity chromatography.
• Synonyms: Connexin 30; GJB6; Gap Junction Protein; beta 6; ; Polyclonal Antibody; (30kDa); Anti -Connexin 30; anti-GJB6 antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes Connexin 30. Species sequence homology
• Purity/Purification: Affinity Purified; Purified by peptide affinity chromatography.
• Form/Format: Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.

• Applicable Applications for anti-GJB6 antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.; Dilution: Peptide ELISA Titer: 1:16,000
• Immunogen: Synthetic peptide corresponding to C-RSKRAQTQKNHPNH, from the internal region of human Connexin 30 (NP_006774.2).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-GJB6 antibody

Gap junctions allow the transport of ions and metabolites between the cytoplasm of adjacent cells. They are formed by two hemichannels, made up of six connexin proteins assembled in groups. Each connexin protein has four transmembrane segments, two extracellular loops, a cytoplasmic loop formed between the two inner transmembrane segments, and the N- and C-terminus both being in the cytoplasm. The specificity of the gap junction is determined by which connexin proteins comprise the hemichannel. In the past, connexin protein names were based on their molecular weight, however the new nomenclature uses sequential numbers based on which form (alpha or beta) of the gap junction is present. This gene encodes one of the connexin proteins. Mutations in this gene have been found in some forms of deafness and in some families with hidrotic ectodermal dysplasia.

Product Categories/Family for anti-GJB6 antibody

Antibodies; Abs to Connexin; Junction Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 55925665
• NCBI GeneID: 10804
• UniProt Accession #: O95452; Q5Q1H9; Q5Q1I0; Q5Q1I1; Q5T5U0; Q8IUP0; B3KQN2
• Molecular Weight: 30,387 Da
• NCBI Official Full Name: connexin 30
• NCBI Official Synonym Full Names: gap junction protein, beta 6, 30kDa
• NCBI Official Symbol: GJB6
• NCBI Official Synonym Symbols: ED2; EDH; HED; CX30; DFNA3; DFNA3B; DFNB1B
• NCBI Protein Information: gap junction beta-6 protein; connexin 30; connexin-30; OTTHUMP00000018096; OTTHUMP00000176870; OTTHUMP00000176871; OTTHUMP00000176872; gap junction protein, beta 6 (connexin 30); ectodermal dysplasia 2, hidrotic (Clouston syndrome)
• UniProt Protein Name: Gap junction beta-6 protein
• Protein Family: Gap junction beta-6 protein
• UniProt Gene Name: GJB6
• UniProt Entry Name: CXB6_HUMAN

NCBI Description

Gap junctions allow the transport of ions and metabolites between the cytoplasm of adjacent cells. They are formed by two hemichannels, made up of six connexin proteins assembled in groups. Each connexin protein has four transmembrane segments, two extracellular loops, a cytoplasmic loop formed between the two inner transmembrane segments, and the N- and C-terminus both being in the cytoplasm. The specificity of the gap junction is determined by which connexin proteins comprise the hemichannel. In the past, connexin protein names were based on their molecular weight, however the new nomenclature uses sequential numbers based on which form (alpha or beta) of the gap junction is present. This gene encodes one of the connexin proteins. Mutations in this gene have been found in some forms of deafness and in some families with hidrotic ectodermal dysplasia. [provided by RefSeq]

Uniprot Description

GJB6: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Belongs to the connexin family. Beta-type (group I) subfamily. A connexon is composed of a hexamer of connexins. Interacts with CNST

Protein type: Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 13q12

Cellular Component: connexon complex; apical plasma membrane; integral to membrane; cytosol

Biological Process: negative regulation of cell proliferation; sensory perception of sound; apoptosis; response to lipopolysaccharide; cell communication; ear morphogenesis; response to electrical stimulus; inner ear development; aging

Disease: Deafness, Autosomal Recessive 1a; Clouston Syndrome; Deafness, Autosomal Recessive 1b; Deafness, X-linked 2; Deafness, Autosomal Dominant 3b