Rabbit anti-Human, Mouse Collagen VI alpha3 Polyclonal Antibody | anti-COL6A3 antibody

Collagen VI alpha3 Antibody

Cat. Num. AAA9401481

• Gene Names: COL6A3; DYT27
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, Immunofluorescence
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: Collagen VI alpha3; Polyclonal Antibody; Collagen VI alpha3 Antibody; Collagen VI a3 Antibody; Collagen alpha-3(VI) chain; CO6A3; anti-COL6A3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total Collagen VI a3 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 3177

• Applicable Applications for anti-COL6A3 antibody: Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: Immunohistochemistry: 1:50~1:100; Immunofluorescence: 1:100~1:500
• Immunogen Type: Peptide
• Immunogen Description: Synthesized peptide derived from internal of human Collagen VI a3.
• Target Name: Collagen VI a3
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using Collagen VI a3 antibody.)

Immunofluorescence (IF)

(Immunofluorescence analysis of HeLa cells, using Collagen VI a3 antibody.)

Related Product Information for anti-COL6A3 antibody

Collagen VI acts as a cell-binding protein.Chu M.-L., EMBO J. 9:385-393(1990).Zanussi S., J. Biol. Chem. 267:24082-24089(1992).Liu T., J. Proteome Res. 4:2070-2080(2005).

Product Categories/Family for anti-COL6A3 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 55743098
• NCBI GeneID: 1293
• NCBI Accession #: NP_004360.2
• NCBI GenBank Nucleotide #: NM_004369.3
• UniProt Accession #: P12111; Q16501; Q53QF4; Q53QF6; A8MT30; B4E3U5; B7ZMJ7; E9PFQ6; E9PGQ9
• Molecular Weight: 134,707 Da
• NCBI Official Full Name: collagen alpha-3(VI) chain isoform 1
• NCBI Official Synonym Full Names: collagen, type VI, alpha 3
• NCBI Official Symbol: COL6A3
• NCBI Official Synonym Symbols: DYT27
• NCBI Protein Information: collagen alpha-3(VI) chain
• UniProt Protein Name: Collagen alpha-3(VI) chain
• Protein Family: Collagen
• UniProt Gene Name: COL6A3
• UniProt Entry Name: CO6A3_HUMAN

NCBI Description

This gene encodes the alpha-3 chain, one of the three alpha chains of type VI collagen, a beaded filament collagen found in most connective tissues. The alpha-3 chain of type VI collagen is much larger than the alpha-1 and -2 chains. This difference in size is largely due to an increase in the number of subdomains, similar to von Willebrand Factor type A domains, that are found in the amino terminal globular domain of all the alpha chains. These domains have been shown to bind extracellular matrix proteins, an interaction that explains the importance of this collagen in organizing matrix components. Mutations in the type VI collagen genes are associated with Bethlem myopathy, a rare autosomal dominant proximal myopathy with early childhood onset. Mutations in this gene are also a cause of Ullrich congenital muscular dystrophy, also referred to as Ullrich scleroatonic muscular dystrophy, an autosomal recessive congenital myopathy that is more severe than Bethlem myopathy. Multiple transcript variants have been identified, but the full-length nature of only some of these variants has been described. [provided by RefSeq, Jun 2009]

Uniprot Description

Collagen VI acts as a cell-binding protein.