Western Blot (WB)
(COL8A1 Antibody (N-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the COL8A1 antibody detected the COL8A1 protein (arrow).)
Rabbit anti-Human COL8A1 Polyclonal Antibody | anti-COL8A1 antibody
COL8A1 Antibody (N-term)
Western Blot (WB)
(COL8A1 Antibody (N-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the COL8A1 antibody detected the COL8A1 protein (arrow).)
Western Blot (WB)
(COL8A1 Antibody (N-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the COL8A1 antibody detected the COL8A1 protein (arrow).)
collagen. The gene product is a short chain collagen and a major
component of the basement membrane of the corneal endothelium. The
type VIII collagen fibril can be either a homo- or a heterotrimer.
Alternatively spliced transcript variants encoding the same isoform
have been observed.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Neale, B.M., et al. Proc. Natl. Acad. Sci. U.S.A. 107(16):7395-7400(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Marroni, F., et al. Circ Cardiovasc Genet 2(4):322-328(2009)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes one of the two alpha chains of type VIII collagen. The gene product is a short chain collagen and a major component of the basement membrane of the corneal endothelium. The type VIII collagen fibril can be either a homo- or a heterotrimer. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Dec 2011]
Uniprot Description
COL8A1: Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis.
Protein type: Secreted; Extracellular matrix; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 3q12.3
Cellular Component: extracellular matrix; intracellular membrane-bound organelle; endoplasmic reticulum lumen; extracellular region; collagen type VIII
Biological Process: collagen catabolic process; extracellular matrix disassembly; epithelial cell proliferation; extracellular matrix organization and biogenesis; camera-type eye morphogenesis; angiogenesis; cell adhesion
Research Articles on COL8A1
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Product Notes
The COL8A1 col8a1 (Catalog #AAA9209770) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 62-89. The COL8A1 Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's COL8A1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the COL8A1 col8a1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "COL8A1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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