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Rabbit COCH Polyclonal Antibody | anti-COCH antibody

COCH

Gene Names
COCH; DFNA9; COCH5B2; DFNB110; COCH-5B2
Reactivity
Human
Predicted: Rat, Mouse
Applications
ELISA, Western Blot
Purity
Purified By Antigen Affinity Column
Synonyms
COCH; Polyclonal Antibody; anti-COCH antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Predicted: Rat, Mouse
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Purified By Antigen Affinity Column
Form/Format
Already dissolved in sterile H2O with 1% BSA and 0.02% NaN3 and 50% Glycerol.
Sequence Length
2007
Applicable Applications for anti-COCH antibody
ELISA (EIA), Western Blot (WB)
Application Notes
ELISA: 1:20,000-80,000
WB: 1:200-1,000
Immunogen
Recombinant fragment corresponding to 80-236aa of human COCH.
Cellular Localization
Extracellular Matrix, Secreted
Related Product Information for anti-COCH antibody
Homo sapiens coagulation factor C homolog, cochlin (Limulus polyphemus), mRNA
References
Tsukada K, Ichinose A, Miyagawa M. et al. Detailed hearing and vestibular profiles in the patients with COCH mutations. Ann Otol Rhinol Laryngol. 124 Suppl 1:100S-10S (2015)

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
Molecular Weight
59KD
NCBI Official Full Name
Homo sapiens coagulation factor C homolog, cochlin (Limulus polyphemus), mRNA
NCBI Official Synonym Full Names
cochlin
NCBI Official Symbol
COCH
NCBI Official Synonym Symbols
DFNA9; COCH5B2; DFNB110; COCH-5B2
NCBI Protein Information
cochlin
Protein Family

NCBI Description

The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated. [provided by RefSeq, Oct 2008]

Research Articles on COCH

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Product Notes

The COCH (Catalog #AAA8561611) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The COCH reacts with Human Predicted: Rat, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's COCH can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). ELISA: 1:20,000-80,000 WB: 1:200-1,000. Researchers should empirically determine the suitability of the COCH for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "COCH, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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