Western Blot (WB)
(Sample Type: Human A549, H441A549, H441)
Rabbit CNTFR Polyclonal Antibody | anti-CNTFR antibody
CNTFR antibody - C-terminal region
Western Blot (WB)
(Sample Type: Human A549, H441A549, H441)
Western Blot (WB)
(Sample Type: Human A549, H441A549, H441)
Western Blot (WB)
(WB Suggested Anti-CNTFR Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: HepG2 cell lysate)
Western Blot (WB)
(WB Suggested Anti-CNTFR Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: HepG2 cell lysate)
Target Description: This gene encodes a hematopoeitin/interferon-class receptor belonging to the cytokine superfamily of receptors. The encoded gene product represents the CNTF-specific alpha subunit of a heterotrimer forming the CNTF receptor complex, which also includes LIFR and gp130. The receptor is attached to the membrane by a glycosyl-phosphatidylinositol linkage and contains an immunoglobulin-like C2-type domain and a fibronectin type-III domain. Signal transduction requires that CNTF bind first to this alpha component, which permits the recruitment of gp130 and LIFR beta to form the tripartite receptor complex. Signal transduction stimulates gene expression, cell survival or differentiation in a variety of neuronal cell types. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]
Uniprot Description
CNTFR: Binds to CNTF. The alpha subunit provides the receptor specificity. Belongs to the type I cytokine receptor family. Type 3 subfamily.
Protein type: Membrane protein, GPI anchor; Receptor, misc.
Chromosomal Location of Human Ortholog: 9p13
Cellular Component: extrinsic to membrane
Molecular Function: cytokine binding; ciliary neurotrophic factor receptor activity; receptor binding
Biological Process: nervous system development; suckling behavior; positive regulation of cell proliferation; negative regulation of neuron apoptosis; signal transduction; sex differentiation
Research Articles on CNTFR
Similar Products
Product Notes
The CNTFR cntfr (Catalog #AAA3214612) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CNTFR antibody - C-terminal region reacts with Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep and may cross-react with other species as described in the data sheet. AAA Biotech's CNTFR can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the CNTFR cntfr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: VAAHATPWTE EPRHLTTEAQ AAETTTSTTS SLAPPPTTKI CDPGELGSGG. It is sometimes possible for the material contained within the vial of "CNTFR, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
