Rabbit CNTFR Polyclonal Antibody | anti-CNTFR antibody

CNTFR antibody

Cat. Num. AAA9403008

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: CNTFR; Polyclonal Antibody; CNTFR antibody; anti-CNTFR antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total CNTFR antibody.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 372

• Applicable Applications for anti-CNTFR antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Western blotting: 1:500 - 1:2000; Immunohistochemistry: 1:50 - 1:100
• Immunogen Type: Recombinant Protein
• Immunogen Description: Recombinant protein of human CNTFR.
• Target Name: CNTFR
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using CNTFR antibody.)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human colon cancer tissue using CNTFR antibody.)

Related Product Information for anti-CNTFR antibody

This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene.

Product Categories/Family for anti-CNTFR antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 333108228
• NCBI GeneID: 1271
• NCBI Accession #: NP_001193940.1
• NCBI GenBank Nucleotide #: NM_001207011.1
• UniProt Accession #: P26992; Q5U050
• Molecular Weight: 40,633 Da
• NCBI Official Full Name: ciliary neurotrophic factor receptor subunit alpha preproprotein
• NCBI Official Synonym Full Names: ciliary neurotrophic factor receptor
• NCBI Official Symbol: CNTFR
• NCBI Protein Information: ciliary neurotrophic factor receptor subunit alpha
• UniProt Protein Name: Ciliary neurotrophic factor receptor subunit alpha
• Protein Family: Ciliary neurotrophic factor receptor
• UniProt Gene Name: CNTFR
• UniProt Synonym Gene Names: CNTF receptor subunit alpha; CNTFR-alpha
• UniProt Entry Name: CNTFR_HUMAN

NCBI Description

This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]

Uniprot Description

CNTFR: Binds to CNTF. The alpha subunit provides the receptor specificity. Belongs to the type I cytokine receptor family. Type 3 subfamily.

Protein type: Receptor, misc.; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 9p13

Cellular Component: extrinsic to membrane

Molecular Function: cytokine binding; ciliary neurotrophic factor receptor activity; receptor binding

Biological Process: nervous system development; suckling behavior; positive regulation of cell proliferation; negative regulation of neuron apoptosis; signal transduction; sex differentiation