Rabbit anti-Human CNRP1 Polyclonal Antibody | anti-CNRP1 antibody

CNRP1, ID (CNRIP1, C2orf32, CB1 cannabinoid receptor-interacting protein 1) (Biotin)

Cat. Num. AAA6287341

• Gene Names: CNRIP1; CRIP1; CRIP-1; C2orf32
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: CNRP1; Polyclonal Antibody; ID (CNRIP1; C2orf32; CB1 cannabinoid receptor-interacting protein 1) (Biotin); CNRIP1; CB1 cannabinoid receptor-interacting protein 1; anti-CNRP1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
• Sequence Length: 164

• Applicable Applications for anti-CNRP1 antibody: Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
• Application Notes: IHC: 1:10-50; ELISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: CNRP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-112 amino acids from the Central region of human CNRP1.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(CNRP1 Antibody (Center) western blot analysis in Y79 cell line lysates (35ug/lane).This demonstrates the CNRP1 antibody detected the CNRP1 protein (arrow).)

Immunohistochemistry (IHC)

(CNRP1 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CNRP1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)

Related Product Information for anti-CNRP1 antibody

This gene encodes a G-protein coupled receptor which interacts with the C-terminal tail of cannabinoid receptor 1. This receptor plays a role in synaptic plasticity, analgesia, appetite, and neuroprotection. Two transcript variants encoding different isoforms have been described for this gene.

Product Categories/Family for anti-CNRP1 antibody

Antibodies; Receptors

References

Rose, J. Phd, et al. Mol. Med. (2010). In press: Gieger, C., et al. PLoS Genet. 4 (11), E1000282 (2008): Niehaus, J.L., et al. Mol. Pharmacol. 72(6):1557-1566(2007). Swick, L., et al. J. Neurochem. 97(5):1447-1455(2006).

NCBI and Uniprot Product Information

• NCBI GI #: 24308071
• NCBI GeneID: 25927
• NCBI Accession #: NP_056278.1; NP_001104571.1
• NCBI GenBank Nucleotide #: NP_056278.1
• UniProt Accession #: Q96F85
• NCBI Official Full Name: CB1 cannabinoid receptor-interacting protein 1 isoform CRIP1a
• NCBI Official Synonym Full Names: cannabinoid receptor interacting protein 1
• NCBI Official Symbol: CNRIP1
• NCBI Official Synonym Symbols: CRIP1; CRIP-1; C2orf32
• NCBI Protein Information: CB1 cannabinoid receptor-interacting protein 1
• UniProt Protein Name: CB1 cannabinoid receptor-interacting protein 1
• UniProt Gene Name: CNRIP1
• UniProt Synonym Gene Names: C2orf32; CRIP-1
• UniProt Entry Name: CNRP1_HUMAN

NCBI Description

This gene encodes a protein that interacts with the C-terminal tail of cannabinoid receptor 1. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2013]

Uniprot Description

CNRIP1: Isoform 1 suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. Isoform 2 does not have this effect. Belongs to the CNRIP family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 2p14