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Western Blot (WB) (Western blot analysis CLCNKB using COLO205 whole cell lysates)

Rabbit anti-Human CLCNKB Polyclonal Antibody | anti-CLCNKB antibody

CLCNKB Antibody

Gene Names
CLCNKB; CLCKB; ClC-K2; ClC-Kb
Reactivity
Human
Applications
Western Blot
Synonyms
CLCNKB; Polyclonal Antibody; CLCNKB Antibody; Bartter syndrome Type 3; Chloride channel; kidney; B; Chloride channel Kb; ClC-Kb; ClC-K2; CLCKB; HClC-Kb; anti-CLCNKB antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Specificity
CLCNKB Antibody detects endogenous levels of total CLCNKB
Form/Format
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0mg/mL (varies by lot)
Sequence Length
687
Applicable Applications for anti-CLCNKB antibody
Western Blot (WB)
Application Notes
Western Blot: 1:1000-3000
Immunogen
A synthesized peptide derived from human CLCNKB
Immunogen Type
Peptide
Preparation and Storage
Store at -20 degree C

Western Blot (WB)

(Western blot analysis CLCNKB using COLO205 whole cell lysates)

Western Blot (WB) (Western blot analysis CLCNKB using COLO205 whole cell lysates)
Product Categories/Family for anti-CLCNKB antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
56,998 Da
NCBI Official Full Name
chloride channel protein ClC-Kb isoform 1
NCBI Official Synonym Full Names
chloride voltage-gated channel Kb
NCBI Official Symbol
CLCNKB
NCBI Official Synonym Symbols
CLCKB; ClC-K2; ClC-Kb
NCBI Protein Information
chloride channel protein ClC-Kb
UniProt Protein Name
Chloride channel protein ClC-Kb
Protein Family
UniProt Gene Name
CLCNKB
UniProt Synonym Gene Names
Chloride channel Kb
UniProt Entry Name
CLCKB_HUMAN

NCBI Description

The protein encoded by this gene is a member of the family of voltage-gated chloride channels. Chloride channels have several functions, including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. This gene is expressed predominantly in the kidney and may be important for renal salt reabsorption. Mutations in this gene are associated with autosomal recessive Bartter syndrome type 3 (BS3). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Uniprot Description

CLCNKB: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms. Defects in CLCNKB are the cause of Bartter syndrome type 3 (BS3); also known as classic Bartter syndrome. It is an autosomal recessive form of often severe intravascular volume depletion due to renal salt-wasting associated with low blood pressure, hypokalemic alkalosis, hypercalciuria, and normal serum magnesium levels. Defects in CLCNKB are a cause of Bartter syndrome type 4B (BS4B). A digenic, recessive disorder characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. Bartter syndrome type 4B is associated with sensorineural deafness. Belongs to the chloride channel (TC 2.A.49) family. CLCNKB subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: chloride ion binding; voltage-gated chloride channel activity

Biological Process: excretion; transport

Disease: Bartter Syndrome, Type 3; Bartter Syndrome, Type 4b

Research Articles on CLCNKB

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Product Notes

The CLCNKB clcnkb (Catalog #AAA9419273) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CLCNKB Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CLCNKB can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:1000-3000. Researchers should empirically determine the suitability of the CLCNKB clcnkb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CLCNKB, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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