Western Blot (WB)
(RASGRP3 rabbit polyclonal antibody. Western Blot analysis of RASGRP3 expression in mouse kidney.)
Rabbit anti-Human, Mouse RASGRP3 Polyclonal Antibody | anti-RASGRP3 antibody
RASGRP3 (Ras Guanyl-releasing Protein 3, Calcium and DAG-regulated Guanine Nucleotide Exchange Factor III, GRP3, Guanine Nucleotide Exchange Factor for Rap1, KIAA0846)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Western Blot (WB)
(RASGRP3 rabbit polyclonal antibody. Western Blot analysis of RASGRP3 expression in mouse kidney.)
Western Blot (WB)
(RASGRP3 rabbit polyclonal antibody. Western Blot analysis of RASGRP3 expression in mouse kidney.)
Western Blot (WB)
(Western Blot analysis of RASGRP3 expression in transfected 293T cell line by RASGRP3 polyclonal antibody. Lane 1: RASGRP3 transfected lysate (78.3kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of RASGRP3 expression in transfected 293T cell line by RASGRP3 polyclonal antibody. Lane 1: RASGRP3 transfected lysate (78.3kD). Lane 2: Non-transfected lysate.)
NCBI and Uniprot Product Information
NCBI Description
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]
Uniprot Description
RASGRP3: Guanine nucleotide exchange factor (GEF) for Ras and Rap1. Belongs to the RASGRP family.
Protein type: GEFs, Ras; GEFs
Chromosomal Location of Human Ortholog: 2p25.1-p24.1
Cellular Component: integral to plasma membrane; perinuclear region of cytoplasm; plasma membrane
Molecular Function: diacylglycerol binding; signal transducer activity; Ras GTPase binding; guanyl-nucleotide exchange factor activity; calcium ion binding; kinase binding; Ras guanyl-nucleotide exchange factor activity
Biological Process: small GTPase mediated signal transduction; Ras protein signal transduction; MAPKKK cascade; positive regulation of GTPase activity
Research Articles on RASGRP3
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Product Notes
The RASGRP3 rasgrp3 (Catalog #AAA643430) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RASGRP3 (Ras Guanyl-releasing Protein 3, Calcium and DAG-regulated Guanine Nucleotide Exchange Factor III, GRP3, Guanine Nucleotide Exchange Factor for Rap1, KIAA0846) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's RASGRP3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Researchers should empirically determine the suitability of the RASGRP3 rasgrp3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MGSSGLGKAA TLDELLCTCI EMFDDNGELD NSYLPRIVLL MHRWYLSSTE LAEKLLCMYR NATGESCNEF RLKICYFMRY WILKFPAEFN LDLGLIRMTE EFREVASQLG YEKHVSLIDI SSIPSYDWMR RVTQRKKVSK KGKACLLFDH LEPIELAEHL TFLEHKSFRR ISFTDYQSYV IHGCLENNPT LERSIALFNG ISKWVQLMVL SKPTPQQRAE VITKFINVAK KLLQLKNFNT LMAVVGGLSH SSISRLKETH SHLSSEVTKN WNEMTELVSS NGNYCNYRKA FADCDGFKIP ILGVHLKDLI AVHVIFPDWT EENKVNIVKM HQLSVTLSEL VSLQNASHHL EPNMDLINLL TLSLDLYHTE DDIYKLSLVL EPRNSKSQPT SPTTPNKPVV PLEWALGVMP KPDPTVINKH IRKLVESVFR NYDHDHDGYI SQEDFESIAA NFPFLDSFCV LDKDQDGLIS KDEMMAYFLR AKSQLHCKMG PGFIHNFQEM TYLKPTFCEH CAGFLWGIIK QGYKCKDCGA NCHKQCKDLL VLACRRFARA PSLSSGHGSL PGSPSLPPAQ DEVFEFPGVT AGHRDLDSRA ITLVTGSSRK ISVRLQRATT SQATQTEPVW SEAGWGDSGS HTFPKMKSKF HDKAAKDKGF AKWENEKPRV HAGVDVVDRG TEFELDQDEG EETRQDGEDG. It is sometimes possible for the material contained within the vial of "RASGRP3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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