Rabbit anti-Human CIKS Polyclonal Antibody | anti-TRAF3IP2 antibody

CIKS Antibody

Cat. Num. AAA151349

• Gene Names: TRAF3IP2; ACT1; CIKS; C6orf2; C6orf4; C6orf5; C6orf6; CANDF8; PSORS13
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: CIKS Antibody is affinity chromatography purified via peptide column.
• Synonyms: CIKS; Polyclonal Antibody; CIKS Antibody; ACT1; C6orf2; C6orf4; C6orf5; C6orf6; CANDF8; PSORS13; Adapter protein CIKS; Nuclear factor NF-kappa-B activator 1; TRAF3 interacting protein 2; anti-TRAF3IP2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: CIKS Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Sequence Length: 2190

• Applicable Applications for anti-TRAF3IP2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: CIKS antibody can be used for detection of CIKS by Western blot at 1 mug/mL. A band at approximately 63 kDa can be detected. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.
• Conjugate: Unconjugated
• Immunogen: CIKS antibody was raised against a 15 amino acid peptide near the carboxy terminus of human CIKS.
• Buffer: CIKS Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: CIKS antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of CIKS expression in human placenta tissue lysate with CIKS antibody at 1 μg /ml.)

Immunohistochemistry (IHC)

(Immunohistochemistry of CIKS in human lung tissue with CIKS antibody at 5 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of CIKS in Human Lung cells with CIKS antibody at 20 μg/mL.)

Related Product Information for anti-TRAF3IP2 antibody

CIKS Antibody: Nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-κB associates with IκB proteins in the cell cytoplasm, which inhibit NF-κB activity. IκB is phosphorylated by IκB kinase (IKK) complex that contains IKKα, IKKβ, and IKKγ. A novel molecule that associates with and activates IKK was recently identified and designated CIKS (for connection to IKK and SAPK/JNK) and Act1 (for NF-κB activator 1). CIKS directly interacts with IKKγ. CIKS/Act1 also activates activating transcription factor (ATF) and activator protein 1 (AP-1) through Jun kinase (JNK). These results indicate that CIKS/Act1 is involved in the inflammation and stress responses. CIKS/Act1 is ubiquitously expressed in human tissues.

NCBI and Uniprot Product Information

• NCBI GI #: 10242289
• NCBI GeneID: 10758
• UniProt Accession #: O43734; Q5R3A3; Q7Z6Q1; Q7Z6Q2; Q7Z6Q3; Q9H5W2; Q9H6Y3; Q9NS14; Q9UG72; B2RAY9; E1P555
• Molecular Weight: 63 kDa
• NCBI Official Full Name: Homo sapiens NFkB-activating protein ACT1 (ACT1) mRNA, complete cds
• NCBI Official Synonym Full Names: TRAF3 interacting protein 2
• NCBI Official Symbol: TRAF3IP2
• NCBI Official Synonym Symbols: ACT1; CIKS; C6orf2; C6orf4; C6orf5; C6orf6; CANDF8; PSORS13
• NCBI Protein Information: adapter protein CIKS; NFkB-activating protein ACT1; connection to IKK and SAPK/JNK; nuclear factor NF-kappa-B activator 1
• UniProt Protein Name: Adapter protein CIKS
• Protein Family: Adapter protein
• UniProt Gene Name: TRAF3IP2
• UniProt Synonym Gene Names: C6orf2; C6orf4; C6orf5; C6orf6; ACT1
• UniProt Entry Name: CIKS_HUMAN

NCBI Description

This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by RefSeq, Aug 2009]

Uniprot Description

TRAF3IP2: Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK. Defects in TRAF3IP2 are the cause of susceptibility to psoriasis type 13 (PSORS13). PSORS13 is a common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 6q21

Molecular Function: protein binding

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; immunoglobulin secretion; B cell apoptosis; humoral immune response

Disease: Candidiasis, Familial, 8; Psoriasis 13, Susceptibility To