Rabbit CIB2 Polyclonal Antibody | anti-CIB2 antibody

CIB2 Rabbit pAb

Cat. Num. AAA4760572

• Gene Names: CIB2; KIP2; USH1J; DFNB48
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity purified
• Synonyms: CIB2; Polyclonal Antibody; CIB2 Rabbit pAb; calcium and integrin binding family member 2; KIP2; USH1J; DFNB48; anti-CIB2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purified
• Form/Format: pH7.4 PBS, 0.05% NaN3, 40% Glycerol
• Concentration: 0.7mg/ml (varies by lot)

• Applicable Applications for anti-CIB2 antibody: Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: WB: 1:500-1:2000; IHC-P: 1:50-1:100
• Immunogen: Fusion protein of human CIB2
• Conjugation: Unconjugated
• Modification: Unmodified
• Preparation and Storage: Store at 4 degree C for short term. Store at -20 degree C for long term. Avoid freeze/thaw cycle.

Western Blot (WB)

(Western Blot analysis of CIB2 in Mouse eye tissue lysate using CIB2 Rabbit pAb at dilution 1/400)

Immunohistochemistry (IHC)

(Immunohistochemistry of CIB2 in paraffin-embedded Human thyroid cancer tissue using CIB2 Rabbit pAb at dilution 1/50. Predicted cell location: Cytoplasm)

Related Product Information for anti-CIB2 antibody

The protein encoded by this gene is similar to that of KIP/CIB, calcineurin B, and calmodulin. The encoded protein is a calcium-binding regulatory protein that interacts with DNA-dependent protein kinase catalytic subunits (DNA-PKcs), and it is involved in photoreceptor cell maintenance. Mutations in this gene cause deafness, autosomal recessive, 48 (DFNB48), and also Usher syndrome 1J (USH1J). Alternative splicing results in multiple transcript variants.

NCBI and Uniprot Product Information

• NCBI GI #: 5453708
• NCBI GeneID: 10518
• NCBI Accession #: NP_006374.1
• NCBI GenBank Nucleotide #: NM_006383.3
• UniProt Accession #: O75838
• Molecular Weight: 21,644 Da
• NCBI Official Full Name: calcium and integrin-binding family member 2 isoform 1
• NCBI Official Synonym Full Names: calcium and integrin binding family member 2
• NCBI Official Symbol: CIB2
• NCBI Official Synonym Symbols: KIP2; USH1J; DFNB48
• NCBI Protein Information: calcium and integrin-binding family member 2; KIP 2; 2810434I23Rik; Usher syndrome 1J (autosomal recessive); DNA-dependent protein kinase catalytic subunit-interacting protein 2
• UniProt Protein Name: Calcium and integrin-binding family member 2
• Protein Family: Calcium and integrin-binding family
• UniProt Gene Name: CIB2
• UniProt Synonym Gene Names: KIP2; KIP 2
• UniProt Entry Name: CIB2_HUMAN

NCBI Description

The protein encoded by this gene is similar to that of KIP/CIB, calcineurin B, and calmodulin. This suggests that the encoded protein may be a calcium-binding regulatory protein that interacts with DNA-dependent protein kinase catalytic subunits (DNA-PKcs). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

Uniprot Description

CIB2: Critical for proper photorecetor cell maintenance and function. May play a role in calcium homeostasis and participate in calcium regulation in the mechanotransduction process

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 15q24

Cellular Component: muscle tendon junction; photoreceptor inner segment; neuromuscular junction; sarcolemma

Molecular Function: integrin binding; protein binding; calcium ion binding

Biological Process: calcium ion homeostasis; photoreceptor cell maintenance

Disease: Deafness, Autosomal Recessive 48; Usher Syndrome, Type Ij