Rabbit anti-Human CIB2 Polyclonal Antibody | anti-CIB2 antibody

CIB2, ID (Calcium and Integrin-binding Family Member 2, Kinase-interacting Protein 2, KIP 2, KIP2)

Cat. Num. AAA6011574

• Gene Names: CIB2; KIP2; USH1J; DFNB48
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: CIB2; Polyclonal Antibody; ID (Calcium and Integrin-binding Family Member 2; Kinase-interacting Protein 2; KIP 2; KIP2); Anti -CIB2; anti-CIB2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human CIB2. Species sequence homology: mouse and rat.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS (without Mg2+, Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.

• Applicable Applications for anti-CIB2 antibody: ELISA (EL/EIA), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA and Immunohistochemistry.; Dilution: ELISA: 1:5000; Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml
• Immunogen: Synthetic peptide corresponding to human CIB2.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry (IHC)

(Human Thyroid, C-cells: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry (IHC)

(Human Adrenal Medulla: Formalin-Fixed, Paraffin-Embedded (FFPE))

Related Product Information for anti-CIB2 antibody

The deduced amino acid sequence of KIP2 is similar to that of KIP/CIB (46% identity, 64% similarity), calcineurin B (39% identity, 56% similarity) and calmodulin (30% identity, 42% similarity). This suggests that KIP2 may possibly be a Ca2+-binding regulatory protein that interacts with DNA-dependent protein kinase catalytic subunit (DNA-PKcs).

Product Categories/Family for anti-CIB2 antibody

Antibodies; Abs to Binding Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 5453708
• NCBI GeneID: 10518
• NCBI Accession #: NP_006374.1
• NCBI GenBank Nucleotide #: NM_006383.3
• UniProt Accession #: O75838
• Molecular Weight: 21,644 Da
• NCBI Official Full Name: calcium and integrin-binding family member 2 isoform 1
• NCBI Official Synonym Full Names: calcium and integrin binding family member 2
• NCBI Official Symbol: CIB2
• NCBI Official Synonym Symbols: KIP2; USH1J; DFNB48
• NCBI Protein Information: calcium and integrin-binding family member 2; KIP 2; 2810434I23Rik; Usher syndrome 1J (autosomal recessive); DNA-dependent protein kinase catalytic subunit-interacting protein 2
• UniProt Protein Name: Calcium and integrin-binding family member 2
• Protein Family: Calcium and integrin-binding family
• UniProt Gene Name: CIB2
• UniProt Synonym Gene Names: KIP2; KIP 2
• UniProt Entry Name: CIB2_HUMAN

NCBI Description

The protein encoded by this gene is similar to that of KIP/CIB, calcineurin B, and calmodulin. This suggests that the encoded protein may be a calcium-binding regulatory protein that interacts with DNA-dependent protein kinase catalytic subunits (DNA-PKcs). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

Uniprot Description

CIB2: Critical for proper photorecetor cell maintenance and function. May play a role in calcium homeostasis and participate in calcium regulation in the mechanotransduction process

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 15q24

Cellular Component: muscle tendon junction; photoreceptor inner segment; neuromuscular junction; sarcolemma

Molecular Function: integrin binding; protein binding; calcium ion binding

Biological Process: calcium ion homeostasis; photoreceptor cell maintenance

Disease: Deafness, Autosomal Recessive 48; Usher Syndrome, Type Ij