Rabbit anti-Human, Rat CHRFAM7A Polyclonal Antibody | anti-CHRFAM7A antibody

CHRFAM7A Antibody

Cat. Num. AAA1498484

• Gene Names: CHRFAM7A; D-10; CHRNA7; CHRNA7-DR1
• Reactivity: Human, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Antigen Affinity Purified
• Synonyms: CHRFAM7A; Polyclonal Antibody; CHRFAM7A Antibody; CHRNA7-DR1; anti-CHRFAM7A antibody

• Host: Rabbit
• Reactivity: Human, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purified
• Sequence Length: 412

• Applicable Applications for anti-CHRFAM7A antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Recommended dilution: WB:1:500-2000; IHC:1:20-1:200
• Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Conjugate: Non-conjugated
• Immunogen: Recombinant human CHRNA7-FAM7A fusion protein protein (1-150aa)
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western blotAll lanes: CHRFAM7A antibody at 3ug/mlLane 1:Jurkat whole cell lysateLane 2:Rat liver tissueSecondaryGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 46kDaObserved band size: 46kDa)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human rectum tissue using MBS1498484 at dilution 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human testis tissue using MBS1498484 at dilution 1:100)

Related Product Information for anti-CHRFAM7A antibody

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. CHRFAM7A is encoded by a hybrid gene consisting of a duplication of exons 5 through 10 of the CHRNA7 gene fused 3-prime to a copy of the FAM7A gene (exons A through E).

NCBI and Uniprot Product Information

• NCBI GI #: 23312388
• NCBI GeneID: 89832
• NCBI Accession #: NP_647536.1
• NCBI GenBank Nucleotide #: NM_139320.1
• UniProt Accession #: Q494W8; A8KAB9
• Molecular Weight: 46,218 Da
• NCBI Official Full Name: CHRNA7-FAM7A fusion protein isoform 1
• NCBI Official Synonym Full Names: CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion
• NCBI Official Symbol: CHRFAM7A
• NCBI Official Synonym Symbols: D-10; CHRNA7; CHRNA7-DR1
• NCBI Protein Information: CHRNA7-FAM7A fusion protein
• UniProt Protein Name: CHRNA7-FAM7A fusion protein
• Protein Family: CHRNA7-FAM7A fusion protein
• UniProt Gene Name: CHRFAM7A
• UniProt Entry Name: CRFM7_HUMAN

NCBI Description

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed. [provided by RefSeq, Jul 2008]

Uniprot Description

CHRFAM7A: Belongs to the ligand-gated ion channel (TC 1.A.9) family

Protein type: Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 15q13.1

Cellular Component: apical plasma membrane; axolemma; external side of plasma membrane; integral to membrane

Molecular Function: extracellular ligand-gated ion channel activity

Biological Process: associative learning; B cell activation; behavioral response to ethanol; behavioral response to nicotine; endocytosis; generation of ovulation cycle rhythm; memory; negative regulation of inflammatory response; negative regulation of interleukin-1 beta production; negative regulation of interleukin-6 production; positive regulation of heart rate in baroreceptor response to decreased systemic arterial blood pressure; regulation of norepinephrine secretion; regulation of synaptic transmission, dopaminergic; response to food; sperm motility; synaptic transmission, cholinergic; T cell activation