Rabbit anti-Human CHM Polyclonal Antibody | anti-CHM antibody

CHM Antibody

Cat. Num. AAA9429638

• Gene Names: CHM; TCD; GGTA; REP-1; DXS540; HSD-32
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: CHM; Polyclonal Antibody; CHM Antibody; TCD; GGTA; REP-1; DXS540; HSD-32; anti-CHM antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: The antibody detects endogenous levels of total CHM protein.
• Purity/Purification: Antigen affinity purification
• Form/Format: In pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
• Concentration: 1.4mg/ml (varies by lot)
• Sequence Length: 653

• Applicable Applications for anti-CHM antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1: 20-100
• Immunogen: Synthetic peptide corresponding to internal residues of human CHM
• Immunogen Type: Peptide
• Preparation and Storage: Store at -20 degree C.

Immunohistochemistry (IHC)

(The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using 46491(CHM Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200))

Immunohistochemistry (IHC)

(The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using 46491(CHM Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200))

Related Product Information for anti-CHM antibody

This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternatively spliced transcript variants have been found for this gene.

Product Categories/Family for anti-CHM antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 9966761
• NCBI GeneID: 1121
• NCBI Accession #: NP_000381
• NCBI GenBank Nucleotide #: NM_000390.3
• UniProt Accession #: P24386; O43732; A1L4D2
• Molecular Weight: 12,301 Da
• NCBI Official Full Name: rab proteins geranylgeranyltransferase component A 1 isoform a
• NCBI Official Synonym Full Names: CHM, Rab escort protein 1
• NCBI Official Symbol: CHM
• NCBI Official Synonym Symbols: TCD; GGTA; REP-1; DXS540; HSD-32
• NCBI Protein Information: rab proteins geranylgeranyltransferase component A 1
• UniProt Protein Name: Rab proteins geranylgeranyltransferase component A 1
• Protein Family: Rab proteins geranylgeranyltransferase component
• UniProt Gene Name: CHM
• UniProt Synonym Gene Names: REP1; TCD; REP-1

NCBI Description

This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]

Uniprot Description

Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation.