Rabbit anti-Human, Mouse CEND1 Polyclonal Antibody | anti-CEND1 antibody

CEND1 Antibody

Cat. Num. AAA9429617

• Gene Names: CEND1; BM88
• Reactivity: Human, Mouse
• Applications: Western Blot, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: CEND1; Polyclonal Antibody; CEND1 Antibody; BM88; anti-CEND1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: The antibody detects endogenous levels of total CEND1 protein.
• Purity/Purification: Antigen affinity purification
• Form/Format: In pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
• Concentration: 1.6mg/ml (varies by lot)
• Sequence Length: 149

• Applicable Applications for anti-CEND1 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500-1:2000; IHC: 1: 40-200
• Immunogen: Synthetic peptide corresponding to internal residues of human CEND1
• Immunogen Type: Peptide
• Preparation and Storage: Store at -20 degree C.

SDS-Page

(Gel: 12%SDS-PAGE lysate: 40 ¦Œg, Lane 1-3: Mouse brain tissueRat brain tissue and Human cerebrum tissue lysates, Primary antibody: 46470£¨CEND1 Antibody) at dilution 1/500 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds)

Immunohistochemistry (IHC)

(The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using 46470(CEND1 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200))

Related Product Information for anti-CEND1 antibody

BM88, also known as CEND1 (cell cycle exit and neuronal differentiation protein 1), is a 149 amino acid protein that belongs to the CEND1 familly. Involved in neuroblastoma cell differentiation, BM88 is a single-pass type IV membrane protein that is neuron specific. It is suggested that BM88 forms a dimer of two identical polypeptides linked by disulfide bridges. BM88 has a central proline-rich region containing four PxxP motifs, which typically bind SRC homology-3 (SH3) domains, as well as a putative C-terminal transmembrane region, and several potential sites for N-glycosylation, myristoylation and phosphorylation. It is also suggested that a novel signaling mechanism exists by which BM88 interferes with calcium release from inositol 1, 4, 5-trisphosphate-sensitive stores and exerts anti-proliferative and anti-apoptotic functions. BM88 is an important molecular target for HDAC inhibition, and transcription of BM88 is induced by trichostatin-A.

Product Categories/Family for anti-CEND1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 30795225
• NCBI GeneID: 51286
• NCBI Accession #: NP_057648
• NCBI GenBank Nucleotide #: NM_016564.3
• UniProt Accession #: Q8N111; Q9NYM6
• Molecular Weight: 15 kDa
• NCBI Official Full Name: cell cycle exit and neuronal differentiation protein 1
• NCBI Official Synonym Full Names: cell cycle exit and neuronal differentiation 1
• NCBI Official Symbol: CEND1
• NCBI Official Synonym Symbols: BM88
• NCBI Protein Information: cell cycle exit and neuronal differentiation protein 1
• UniProt Protein Name: Cell cycle exit and neuronal differentiation protein 1
• Protein Family: Cell cycle exit and neuronal differentiation protein
• UniProt Gene Name: CEND1
• UniProt Synonym Gene Names: BM88

NCBI Description

The protein encoded by this gene is a neuron-specific protein. The similar protein in pig enhances neuroblastoma cell differentiation in vitro and may be involved in neuronal differentiation in vivo. Multiple pseudogenes have been reported for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Involved in neuronal differentiation.