Rabbit CEND1 Polyclonal Antibody | anti-CEND1 antibody

CEND1 Polyclonal Antibody

Cat. Num. AAA2559680

• Gene Names: CEND1; BM88
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, ELISA
• Purity: Antigen Affinity Purification
• Synonyms: CEND1; Polyclonal Antibody; CEND1 Polyclonal Antibody; BM88; BM88 antigen; Cell cycle exit and neuronal differentiation 1; Cell cycle exit and neuronal differentiation protein 1; FLJ90066; MGC34326; anti-CEND1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
• Concentration: 0.5mg/mL (varies by lot)
• Sequence Length: 149

• Applicable Applications for anti-CEND1 antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:25-1:100; ELISA: 1:5000-1:10000
• Immunogen: Synthetic peptide of human CEND1
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using CEND1 Polyclonal Antibody at dilution of 1:30(×200))

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human prost ate cancer tissue using CEND1 Polyclonal Antibody at dilution of 1:30(×200))

Related Product Information for anti-CEND1 antibody

BM88, also known as CEND1 (cell cycle exit and neuronal differentiation protein 1), is a 149 amino acid protein that belongs to the CEND1 familly. Involved in neuroblastoma cell differentiation, BM88 is a single-pass type IV membrane protein that is neuron specific. It is suggested that BM88 forms a dimer of two identical polypeptides linked by disulfide bridges. BM88 has a central proline-rich region containing four PxxP motifs, which typically bind SRC homology-3 (SH3) domains, as well as a putative C-terminal transmembrane region, and several potential sites for N-glycosylation, myristoylation and phosphorylation. It is also suggested that a novel signaling mechanism exists by which BM88 interferes with calcium release from inositol 1,4,5-trisphosphate-sensitive stores and exerts anti-proliferative and anti-apoptotic functions. BM88 is an important molecular target for HDAC inhibition, and transcription of BM88 is induced by trichostatin-A.

Product Categories/Family for anti-CEND1 antibody

Cancer; Cell Biology; Neuroscience; Tags & Cell Markers

NCBI and Uniprot Product Information

• NCBI GI #: 30795225
• NCBI GeneID: 51286
• NCBI Accession #: NP_057648.2
• NCBI GenBank Nucleotide #: NP_057648.2
• UniProt Accession #: Q8N111
• NCBI Official Full Name: cell cycle exit and neuronal differentiation protein 1
• NCBI Official Synonym Full Names: cell cycle exit and neuronal differentiation 1
• NCBI Official Symbol: CEND1
• NCBI Official Synonym Symbols: BM88
• NCBI Protein Information: cell cycle exit and neuronal differentiation protein 1
• UniProt Protein Name: Cell cycle exit and neuronal differentiation protein 1
• Protein Family: Cell cycle exit and neuronal differentiation protein
• UniProt Gene Name: CEND1
• UniProt Synonym Gene Names: BM88
• UniProt Entry Name: CEND_HUMAN

NCBI Description

The protein encoded by this gene is a neuron-specific protein. The similar protein in pig enhances neuroblastoma cell differentiation in vitro and may be involved in neuronal differentiation in vivo. Multiple pseudogenes have been reported for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

CEND1: Involved in neuroblastoma cell differentiation. Homodimer. Neuron specific. Belongs to the CEND1 family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: integral to membrane

Biological Process: negative regulation of granule cell precursor proliferation; cerebellar Purkinje cell differentiation; adult walking behavior; cerebellar granular layer maturation; radial glia guided migration of granule cell