Goat CDX2 Polyclonal Antibody | anti-CDX2 antibody

GOAT ANTI HUMAN CDX2

Cat. Num. AAA223121

• Gene Names: CDX2; CDX3; CDX-3; CDX2/AS
• Reactivity: Dog (Expected from Sequence), Mouse (Expected from Sequence), Rat (Expected from Sequence)
• Applications: ELISA, Western Blot
• Synonyms: CDX2; Polyclonal Antibody; GOAT ANTI HUMAN CDX2; anti-CDX2 antibody

• Host: Goat
• Reactivity: Dog (Expected from Sequence), Mouse (Expected from Sequence), Rat (Expected from Sequence)
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: This item specifically recognises human CDX2 (caudal-type homeobox protein 2), a nuclear protein and member of the caudal homeobox family, which acts as a regulator for intestinal epithelium gene transcription, and possibly for the differentiation and proliferation of intestinal epithelial cells. ; ; Studies have revealed the expression of CDX2 in intestinal-type gastric cancer, colorectal carcinomas and intestinal metaplasia of the stomach, and have implicated CDX2 as an early marker of Barrett's oesophagus, the premalignant lesion of oesophageal adenocarcinoma (EAC). ; ; This item is not expected to recognise CDX1 or CDX4.
• Form/Format: Purified; Purified IgG - liquid
• Concentration: IgG concentration 0.5mg/ml (varies by lot)
• Sequence Length: 313

• Applicable Applications for anti-CDX2 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: Western Blot: This item detects a band of approximately 38kDa in human kidney and liver cell lysates.; ELISA: Maximum Dilution: 1/4000; Western Blotting: Minimum Dilution: 1.0; Maximum Dilution: 3.0ug/ml
• Perservative Stabilisers: 0.02% Sodium Azide (NaN3); 0.5% Bovine Serum Albumin
• Immunogen: Peptide sequence EQLSPGGQRRNLCE corresponding to the internal region of CDX2 (NP_001256.1).; Buffer Solution
• Antiserum Preparation: Antiserum to human CDX2 was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
• Target Species: Human
• Preparation and Storage: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.; Shelf Life: 18 months from date of despatch.

Related Product Information for anti-CDX2 antibody

MBS223121 specifically recognises human CDX2 (caudal-type homeobox protein 2), a nuclear protein and member of the caudal homeobox family, which acts as a regulator for intestinal epithelium gene transcription, and possibly for the differentiation and proliferation of intestinal epithelial cells. Studies have revealed the expression of CDX2 in intestinal-type gastric cancer, colorectal carcinomas and intestinal metaplasia of the stomach, and have implicated CDX2 as an early marker of Barrett's oesophagus, the premalignant lesion of oesophageal adenocarcinoma (EAC). MBS223121 is not expected to recognise CDX1 or CDX4.

NCBI and Uniprot Product Information

• NCBI GI #: 372624392
• NCBI GeneID: 1045
• NCBI Accession #: NP_001256.3
• NCBI GenBank Nucleotide #: NM_001265.4
• UniProt Accession #: Q99626; O00503; Q5VTU7; Q969L8; Q9UD92
• Molecular Weight: 33,520 Da
• NCBI Official Full Name: homeobox protein CDX-2
• NCBI Official Synonym Full Names: caudal type homeobox 2
• NCBI Official Symbol: CDX2
• NCBI Official Synonym Symbols: CDX3; CDX-3; CDX2/AS
• NCBI Protein Information: homeobox protein CDX-2; caudal type homeo box transcription factor 2; caudal type homeobox transcription factor 2; caudal-type homeobox protein 2
• UniProt Protein Name: Homeobox protein CDX-2
• Protein Family: Homeobox protein
• UniProt Gene Name: CDX2
• UniProt Synonym Gene Names: CDX3
• UniProt Entry Name: CDX2_HUMAN

NCBI Description

This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012]

Uniprot Description

CDX2: Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Belongs to the Caudal homeobox family.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 13q12.3

Cellular Component: nucleoplasm; condensed nuclear chromosome; transcriptional repressor complex

Molecular Function: double-stranded DNA binding; transcription factor activity; transcription corepressor activity

Biological Process: transcription from RNA polymerase II promoter; anterior/posterior pattern formation; establishment and/or maintenance of epithelial cell polarity; blood vessel development; organ morphogenesis; somatic stem cell maintenance; positive regulation of transcription, DNA-dependent; positive regulation of cell proliferation; endosome to lysosome transport; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell differentiation; trophectodermal cell differentiation