Immunohistochemistry (IHC)
(Immunochemical staining of human CDKN1C in human kidney with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human CDKN1C Polyclonal Antibody | anti-CDKN1C antibody
Anti-CDKN1C Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
CDKN1C; Polyclonal Antibody; Anti-CDKN1C Antibody; Rabbit Polyclonal; CDKN1C Antibody; Rabbit PAb; Antigen Affinity Purified; Anti-BWCR Antibody; Anti-BWS Antibody; Anti-KIP2 Antibody; Anti-p57 Antibody; Anti-p57Kip2 Antibody; Anti-WBS Antibody; anti-CDKN1C antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human CDKN1C
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-CDKN1C antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:500-1:2000
Immunogen
E Coli-derived Human CDKN1C fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human CDKN1C fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human CDKN1C in human kidney with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human CDKN1C in human kidney with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human CDKN1C in human placenta with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human CDKN1C in human placenta with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-CDKN1C antibody
CDKN1C is a cyclin-dependent kinase Inhibitor and negative regulator of cellular proliferation. The CDKN1C gene encodes the p57Kip2 protein which has been identified as the third member of the CIP/Kip family. p57Kip2 can bind tightly and inhibit cyclin/cyclin-dependent kinase complexes and, in turn, modulate cell division cycle progression. Loss-of-function variants in CDKN1C are associated with an overgrowth condition (Beckwith-Wiedemann Syndrome) whereas "gain-of-function" variants in CDKN1C that increase protein stability cause growth restriction as part of IMAGe syndrome (Intrauterine growth restriction, Metaphyseal dysplasia, Adrenal hypoplasia, and Genital anomalies). Gain-of-function mutations in the PCNA domain of CDKN1C are the genetic basis of various growth-retarded syndromes including IMAGe syndrome, Russell Silver syndrome as well as a novel undergrowth syndrome that additionally exhibited early adulthood onset diabetes.
References
Suntharalingham JP, et al. (2019) Analysis of cdkn1c in fetal growth restriction and pregnancy loss. F1000Res 8 90.Stampone E, et al. (2018) Genetic and epigenetic control of cdkn1c expression: Importance in cell commitment and differentiation, tissue homeostasis and human diseases. Int J Mol Sci 19 (4): 1055.Cabrera-Salcedo C, et al. (2017) Image and related undergrowth syndromes: The complex spectrum of gain-of-function cdkn1c mutations. Pediatr Endocrinol Rev 14 (3): 289-297.
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Product Notes
The CDKN1C (Catalog #AAA8110351) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-CDKN1C Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CDKN1C can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:500-1:2000. Researchers should empirically determine the suitability of the CDKN1C for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CDKN1C, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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