Western Blot (WB)
(Anti-Cdk7 antibody, MBS176269, Western blottingAll lanes: Anti Cdk7 (MBS176269) at 0.5ug/mlLane 1: Rat Testis Tissue Lysate at 50ugLane 2: Rat Ovary Tissue Lysate at 50ugLane 3: HELA Whole Cell Lysate at 40ugLane 4: MCF-7 Whole Cell Lysate at 40ugLane 5: A549 Whole Cell Lysate at 40ugLane 6: COLO320 Whole Cell Lysate at 40ugPredicted bind size: 39KDObserved bind size: 39KD)
Rabbit Cdk7 Polyclonal Antibody | anti-CDK7 antibody
Anti-Cdk7 antibody
Western Blot (WB)
(Anti-Cdk7 antibody, MBS176269, Western blottingAll lanes: Anti Cdk7 (MBS176269) at 0.5ug/mlLane 1: Rat Testis Tissue Lysate at 50ugLane 2: Rat Ovary Tissue Lysate at 50ugLane 3: HELA Whole Cell Lysate at 40ugLane 4: MCF-7 Whole Cell Lysate at 40ugLane 5: A549 Whole Cell Lysate at 40ugLane 6: COLO320 Whole Cell Lysate at 40ugPredicted bind size: 39KDObserved bind size: 39KD)
Western Blot (WB)
(Anti-Cdk7 antibody, MBS176269, Western blottingAll lanes: Anti Cdk7 (MBS176269) at 0.5ug/mlLane 1: Rat Testis Tissue Lysate at 50ugLane 2: Rat Ovary Tissue Lysate at 50ugLane 3: HELA Whole Cell Lysate at 40ugLane 4: MCF-7 Whole Cell Lysate at 40ugLane 5: A549 Whole Cell Lysate at 40ugLane 6: COLO320 Whole Cell Lysate at 40ugPredicted bind size: 39KDObserved bind size: 39KD)
Background: Cyclin-dependent kinase 7, also known as cell division protein kinase 7, is an enzyme that in humans is encoded by the CDK7 gene. The protein encoded by this gene is a member of the cyclin-dependent protein kinase(CDK) family. The gene was assigned to human chromosome 5q13.2. Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. CDK7 is the catalytic subunit of the CDK-activating kinase(CAK) complex. It is required for DNA-bound peptides-mediated transcription and cellular growth inhibition.
NCBI and Uniprot Product Information
Uniprot Description
CDK7: a protein kinase of the CDK family. Forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). Activates the cyclin-associated kinases CDK1, -2, -4 and -6. An essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. Serves as a direct link between the regulation of transcription and the cell cycle. Phosphorylates and activates RNA polymerase II, allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
Protein type: Kinase, protein; EC 2.7.11.23; EC 2.7.11.22; Nuclear receptor co-regulator; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CMGC; Cell cycle regulation; CMGC group; CDK family; CDK7 subfamily; CDK/CDK7 subfamily
Cellular Component: nucleoplasm; cytoskeleton; holo TFIIH complex; membrane; mitochondrion; cytoplasm; cytosol; nucleus
Molecular Function: protein C-terminus binding; DNA-dependent ATPase activity; nucleotide binding; protein kinase activity; RNA polymerase subunit kinase activity; transferase activity; protein serine/threonine kinase activity; protein binding; cyclin-dependent protein kinase activity; transferase activity, transferring phosphorus-containing groups; protein complex binding; kinase activity; ATP binding
Biological Process: transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; transcription, DNA-dependent; regulation of cell cycle; cell division; positive regulation of transcription from RNA polymerase II promoter; cell cycle; DNA repair; protein amino acid phosphorylation; phosphorylation; response to DNA damage stimulus
Research Articles on CDK7
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Product Notes
The CDK7 cdk7 (Catalog #AAA176269) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Cdk7 antibody reacts with Human, Rat, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Cdk7 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the CDK7 cdk7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cdk7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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