Western Blot (WB)
(CDC42EP2 Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the CDC42EP2 antibody detected the CDC42EP2 protein (arrow).)
Rabbit anti-Human, mouse CDC42EP2 Polyclonal Antibody | anti-CDC42EP2 antibody
CDC42EP2 Antibody (C-term)
Western Blot (WB)
(CDC42EP2 Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the CDC42EP2 antibody detected the CDC42EP2 protein (arrow).)
Western Blot (WB)
(CDC42EP2 Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the CDC42EP2 antibody detected the CDC42EP2 protein (arrow).)
Western Blot (WB)
(CDC42EP2 Antibody (C-term) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the CDC42EP2 antibody detected the CDC42EP2 protein (arrow).)
Western Blot (WB)
(CDC42EP2 Antibody (C-term) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the CDC42EP2 antibody detected the CDC42EP2 protein (arrow).)
F-actin-containing structures through its interaction with the
downstream effector proteins. The protein encoded by this gene is a
member of the Borg family of CDC42 effector proteins. Borg family
proteins contain a CRIB (Cdc42/Rac interactive-binding) domain.
They bind to, and negatively regulate the function of, CDC42.
Coexpression of this protein with dominant negative mutant CDC42
protein in fibroblast was found to induce pseudopodia formation,
which suggested a role of this protein in actin filament assembly
and cell shape control.
Joberty, G., et al. Nat. Cell Biol. 3(10):861-866(2001)
Hirsch, D.S., et al. J. Biol. Chem. 276(2):875-883(2001)
Joberty, G., et al. Mol. Cell. Biol. 19(10):6585-6597(1999)
Burbelo, P.D., et al. Proc. Natl. Acad. Sci. U.S.A. 96(16):9083-9088(1999)
NCBI and Uniprot Product Information
NCBI Description
CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of CDC42. Coexpression of this protein with CDC42 suggested a role of this protein in actin filament assembly and cell shape control. [provided by RefSeq, Aug 2011]
Uniprot Description
CDC42EP2: Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner. Belongs to the BORG/CEP family.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 11q13
Cellular Component: microtubule cytoskeleton; membrane; cytoplasm; plasma membrane; endomembrane system
Molecular Function: protein binding; opioid peptide activity; GTP-Rho binding
Biological Process: regulation of cell shape; positive regulation of pseudopodium formation; positive regulation of protein complex assembly; positive regulation of actin filament polymerization; actin filament organization; actin cytoskeleton organization and biogenesis
Research Articles on CDC42EP2
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Product Notes
The CDC42EP2 cdc42ep2 (Catalog #AAA9202357) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 133-160. The CDC42EP2 Antibody (C-term) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CDC42EP2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the CDC42EP2 cdc42ep2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CDC42EP2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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