Goat anti-Human CDC42BPA Polyclonal Antibody | anti-CDC42BPA antibody

CDC42BPA, NT (Serine/Threonine-protein Kinase MRCK alpha, CDC42-binding Protein Kinase alpha, DMPK-like alpha, Myotonic Dystrophy Kinase-related CDC42-binding Kinase alpha, MRCK alpha, Myotonic Dystrophy Protein Kinase-like alpha, KIAA0451)

Cat. Num. AAA6010193

• Gene Names: CDC42BPA; MRCK; MRCKA; PK428
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: CDC42BPA; Polyclonal Antibody; NT (Serine/Threonine-protein Kinase MRCK alpha; CDC42-binding Protein Kinase alpha; DMPK-like alpha; Myotonic Dystrophy Kinase-related CDC42-binding Kinase alpha; MRCK alpha; Myotonic Dystrophy Protein Kinase-like alpha; KIAA0451); Anti -CDC42BPA; anti-CDC42BPA antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human CDC42BPA. Species sequence homology: Mouse, rat.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in Tris saline buffer, pH 7.3, 0.5% BSA, 0.02% sodium azide.

• Applicable Applications for anti-CDC42BPA antibody: ELISA (EL/EIA), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA and Immunohistochemistry.; Dilution: ELISA: 1:16,000; Immunohistochemistry (Formalin fixed paraffin embedded): 3.75ug/ml
• Immunogen: Synthetic peptide corresponding to SGEVRLRQLEQFI-C of human CDC42BPA at N-terminal.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Human Brain, Cerebellum: Formalin-Fixed, Paraffin- Embedded (FFPE))

Immunohistochemistry (IHC)

(Human Small Intestine, Submucosal Plexus: Formalin- Fixed, Paraffin-Embedded (FFPE))

Related Product Information for anti-CDC42BPA antibody

May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation.

Product Categories/Family for anti-CDC42BPA antibody

Antibodies; Abs to Protein Kinases

NCBI and Uniprot Product Information

• NCBI GI #: 223462007
• NCBI GeneID: 8476
• UniProt Accession #: Q5VT25; O75039; Q59GZ1; Q5H9N9; Q5T797; Q5VT26; Q5VT27; Q86XX2; Q86XX3; Q99646
• Molecular Weight: 197,307 Da
• NCBI Official Full Name: CDC42BPA protein
• NCBI Official Synonym Full Names: CDC42 binding protein kinase alpha (DMPK-like)
• NCBI Official Symbol: CDC42BPA
• NCBI Official Synonym Symbols: MRCK; MRCKA; PK428
• NCBI Protein Information: serine/threonine-protein kinase MRCK alpha; DMPK-like alpha; ser-thr protein kinase PK428; CDC42 binidng protein kinase beta; myotonic dystrophy protein kinase-like alpha; CDC42-binding protein kinase alpha (DMPK-like); myotonic dystrophy kinase-related CDC42-binding kinase alpha; myotonic dystrophy kinase-related CDC42-binding protein kinase alpha; ser-thr protein kinase related to the myotonic dystrophy protein kinase
• UniProt Protein Name: Serine/threonine-protein kinase MRCK alpha
• Protein Family: Serine/threonine-protein kinase
• UniProt Gene Name: CDC42BPA
• UniProt Synonym Gene Names: KIAA0451; MRCK alpha
• UniProt Entry Name: MRCKA_HUMAN

NCBI Description

The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. [provided by RefSeq, Jul 2008]

Uniprot Description

MRCKA: Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, AGC; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; AGC group; DMPK family; GEK subfamily

Chromosomal Location of Human Ortholog: 1q42.11

Cellular Component: leading edge; cytoplasm; actomyosin; intercellular junction

Molecular Function: protein serine/threonine kinase activity; identical protein binding; protein binding; magnesium ion binding; ATP binding

Biological Process: cell migration; regulation of catalytic activity; actin cytoskeleton reorganization; actomyosin structure organization and biogenesis; microtubule cytoskeleton organization and biogenesis; nuclear migration; protein amino acid phosphorylation