Rabbit anti-Human CDA / Cytidine Deaminase Polyclonal Antibody | anti-CDA antibody

Rabbit Polyclonal to Human CDA / Cytidine Deaminase

Cat. Num. AAA241714

• Gene Names: CDA; CDD
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: CDA / Cytidine Deaminase; Polyclonal Antibody; Rabbit Polyclonal to Human CDA / Cytidine Deaminase; Anti-CDA / Cytidine Deaminase Antibody (N-Terminus) IHC-plus; CDA; Cytidine aminohydrolase; Cytidine deaminase; Small cytidine deaminase; CDD; Cytosine nucleoside deaminase; Human CDA; Cytidine Deaminase; anti-CDA antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: synthetic peptide corresponding to N-terminal residues of human Cytidine deaminase (Cytidine aminohydrolase)
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.01% sodium azide, 50% glycerol.
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 146

• Applicable Applications for anti-CDA antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA (1 ug/ml), IHC-P (5 ug/ml), WB (1 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
• Target Species: Human
• Immunogen Description: Synthetic peptide from human CDA / Cytidine Deaminase.
• Immunogen Type: Synthetic peptide
• Immunogen: CDA / Cytidine Deaminase antibody was raised against synthetic peptide from human CDA / Cytidine Deaminase.
• Antigen Modification: N-Terminus
• Preparation and Storage: Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.

Immunohistochemistry (IHC)

(Anti-Cytidine Deaminase antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Related Product Information for anti-CDA antibody

Cytidine deaminase (CDA), an enzyme involved in pyrimidine salvaging, forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. CDA is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in CDA are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias.

NCBI and Uniprot Product Information

• NCBI GI #: 11386157
• NCBI GeneID: 978
• NCBI Accession #: NP_001776.1
• NCBI GenBank Nucleotide #: NM_001785.2
• Molecular Weight: 16,185 Da
• NCBI Official Full Name: cytidine deaminase
• NCBI Official Synonym Full Names: cytidine deaminase
• NCBI Official Symbol: CDA
• NCBI Official Synonym Symbols: CDD
• NCBI Protein Information: cytidine deaminase; cytidine aminohydrolase; small cytidine deaminase; cytosine nucleoside deaminase
• UniProt Protein Name: Cytidine deaminase
• Protein Family: Colicin
• UniProt Gene Name: CDA
• UniProt Synonym Gene Names: CDD
• UniProt Entry Name: CDD_HUMAN

NCBI Description

This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. [provided by RefSeq, Jul 2008]

Uniprot Description

CDA: This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. Belongs to the cytidine and deoxycytidylate deaminase family.

Protein type: Xenobiotic Metabolism - drug metabolism - other enzymes; Hydrolase; Nucleotide Metabolism - pyrimidine; EC 3.5.4.5

Chromosomal Location of Human Ortholog: 1p36.2-p35

Cellular Component: extracellular region; cytosol

Molecular Function: protein homodimerization activity; zinc ion binding; nucleoside binding; cytidine deaminase activity

Biological Process: cell surface receptor linked signal transduction; pyrimidine base metabolic process; cytosine metabolic process; nucleobase, nucleoside and nucleotide metabolic process; cytidine deamination; pyrimidine nucleoside salvage; negative regulation of cell growth; pyrimidine salvage; negative regulation of nucleotide metabolic process; protein homotetramerization