Rabbit anti-Human CD68 Polyclonal Antibody | anti-CD68 antibody

CD68 Antibody

Cat. Num. AAA9406591

• Gene Names: CD68; GP110; LAMP4; SCARD1
• Reactivity: Human
• Applications: Western Blot
• Purity: Antibodies were purified by antigen-affinity chromatography.
• Synonyms: CD68; Polyclonal Antibody; CD68 Antibody; DKFZp686M18236 antibody; GP110 antibody; SCARD1 antibody; CD68 antibody; macrosialin antibody; "scavenger receptor class D; member 1 antibody"; macrophage antigen CD68 antibody; CD68 antigen antibody; CD68 molecule antibody; anti-CD68 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total CD68 protein.
• Purity/Purification: Antibodies were purified by antigen-affinity chromatography.
• Form/Format: Rabbit IgG in 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: 0.62 mg/ml (varies by lot)
• Sequence Length: 327

• Applicable Applications for anti-CD68 antibody: Western Blot (WB)
• Application Notes: Western blotting: 1:500-1:3000
• Immunogen Type: Recombinant Protein
• Immunogen Description: Recombinant fragment corresponding to a region within amino acids 1 and 194 of CD68.
• Target Name: CD68
• Preparation and Storage: Store at -20 degree C

Testing Data

(Sample (30 ug of whole cell lysate) A: K562 B: THP-1 7.5% SDS PAGE diluted at 1:500)

Related Product Information for anti-CD68 antibody

This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq]

Product Categories/Family for anti-CD68 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 91199550
• NCBI GeneID: 968
• NCBI Accession #: NP_001035148.1
• NCBI GenBank Nucleotide #: NM_001040059.1
• UniProt Accession #: P34810; Q53HR6; Q53XI3; Q96BI7; B4DVT4
• Molecular Weight: 34,654 Da
• NCBI Official Full Name: macrosialin isoform B
• NCBI Official Synonym Full Names: CD68 molecule
• NCBI Official Symbol: CD68
• NCBI Official Synonym Symbols: GP110; LAMP4; SCARD1
• NCBI Protein Information: macrosialin
• UniProt Protein Name: Macrosialin
• Protein Family: Macrosialin
• UniProt Gene Name: CD68
• UniProt Entry Name: CD68_HUMAN

NCBI Description

This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

CD68: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells. Belongs to the LAMP family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 17p13

Cellular Component: membrane; lysosomal membrane; integral to membrane; plasma membrane; endosome membrane