Western Blot (WB)
(Anti- CD36 Picoband antibody, MBS177847, Western blottingAll lanes: Anti CD36 (MBS177847) at 0.5ug/mlLane 1: Rat Liver Tissue Lysate at 50ugLane 2: Rat Cardiac Muscle Tissue Lysate at 50ugLane 3: Mouse Liver Tissue Lysate at 50ugLane 4: Mouse Cardiac Muscle Tissue Lysate at 50ugLane 5: SMMC Whole Cell Lysate at 40ugPredicted bind size: 53KDObserved bind size: 88KD )
CD36 Polyclonal Antibody | anti-CD36 antibody
Anti-CD36 Antibody
Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml
Western Blot (WB)
(Anti- CD36 Picoband antibody, MBS177847, Western blottingAll lanes: Anti CD36 (MBS177847) at 0.5ug/mlLane 1: Rat Liver Tissue Lysate at 50ugLane 2: Rat Cardiac Muscle Tissue Lysate at 50ugLane 3: Mouse Liver Tissue Lysate at 50ugLane 4: Mouse Cardiac Muscle Tissue Lysate at 50ugLane 5: SMMC Whole Cell Lysate at 40ugPredicted bind size: 53KDObserved bind size: 88KD )
Western Blot (WB)
(Anti- CD36 Picoband antibody, MBS177847, Western blottingAll lanes: Anti CD36 (MBS177847) at 0.5ug/mlLane 1: Rat Liver Tissue Lysate at 50ugLane 2: Rat Cardiac Muscle Tissue Lysate at 50ugLane 3: Mouse Liver Tissue Lysate at 50ugLane 4: Mouse Cardiac Muscle Tissue Lysate at 50ugLane 5: SMMC Whole Cell Lysate at 40ugPredicted bind size: 53KDObserved bind size: 88KD )
Immunohistochemistry (IHC)
(Anti- CD36 Picoband antibody, MBS177847, IHC(P)IHC(P): Rat Spleen Tissue )
Immunohistochemistry (IHC)
(Anti- CD36 Picoband antibody, MBS177847, IHC(P)IHC(P): Rat Spleen Tissue )
Background: CD36 (cluster of differentiation 36), also known as FAT (fatty acid translocase), FAT/CD36, (FAT)/CD36, SCARB3, GP88, glycoprotein IV (gpIV), and glycoprotein IIIb (gpIIIb), is anintegral membrane protein found on the surface of many cell types in vertebrate animals. CD36 is a member of the class B scavenger receptor family of cell surface proteins. It is mapped to 7q21.11. And CD36 binds many ligands including collagen, thrombospondin, erythrocytes parasitized with Plasmodium falciparum, oxidized low density lipoprotein, native lipoproteins, oxidized phospholipids, and long-chain fatty acids. In addition, CD36 function in long-chain fatty acid uptake and signaling can be irreversibly inhibited by sulfo-N-succinimidyl oleate (SSO), which binds lysine 164 within a hydrophobic pocked shared by several CD36 ligands, e.g. fatty acid and oxLDL.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014]
Uniprot Description
CD36: Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. Defects in CD36 are the cause of platelet glycoprotein IV deficiency (PG4D)[MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7). Belongs to the CD36 family.
Protein type: Membrane protein, integral; Cell adhesion; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 7q11.2
Cellular Component: apical plasma membrane; brush border membrane; cell surface; cytosol; external side of plasma membrane; extracellular space; Golgi apparatus; integral to plasma membrane; lipid raft; membrane; phagocytic vesicle; plasma membrane; platelet alpha granule membrane
Molecular Function: high-density lipoprotein binding; lipid binding; low-density lipoprotein binding; low-density lipoprotein receptor activity; protein binding; transforming growth factor beta binding
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; apoptotic cell clearance; blood coagulation; cell adhesion; cell surface receptor linked signal transduction; cGMP-mediated signaling; cholesterol absorption; cholesterol transport; defense response to Gram-positive bacterium; elevation of cytosolic calcium ion concentration; immune response; interleukin-1 beta secretion; intestinal absorption; lipid metabolic process; lipoprotein transport; low density lipoprotein mediated signaling; MyD88-dependent toll-like receptor signaling pathway; negative regulation of transcription factor import into nucleus; negative regulation of transcription from RNA polymerase II promoter; nitric oxide mediated signal transduction; phagocytosis, recognition; platelet degranulation; positive regulation of blood coagulation; positive regulation of cell-matrix adhesion; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-12 production; positive regulation of interleukin-6 production; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phagocytosis, engulfment; positive regulation of tumor necrosis factor production; receptor internalization; receptor-mediated endocytosis; response to lipid; sensory perception of taste; sequestering of lipid; triacylglycerol transport
Disease: Coronary Heart Disease, Susceptibility To, 7; Malaria, Susceptibility To; Platelet Glycoprotein Iv Deficiency
Research Articles on CD36
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Product Notes
The CD36 cd36 (Catalog #AAA177847) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-CD36 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CD36 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Western Blot Concentration: 0.1-0.5ug/ml Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml. Researchers should empirically determine the suitability of the CD36 cd36 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD36, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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