Rabbit anti-Human CD28 Polyclonal Antibody | anti-CD28 antibody

CD28 antibody

Cat. Num. AAA536158

• Gene Names: CD28; Tp44
• Reactivity: Human
• Applications: Western Blot
• Purity: CD28 antibody was purified by affinity chromatography.
• Synonyms: CD28; Polyclonal Antibody; CD28 antibody; Polyclonal CD28; Anti-CD28; CD 28; CD -28; anti-CD28 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: CD28 antibody was purified by affinity chromatography.
• Form/Format: Affinity purified IgG supplied in PBS with 0.02% NaN3.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 220

• Applicable Applications for anti-CD28 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1,000
• Biological Significance: CD28 is a T-cell-specific cell-surface receptor that is responsible for enhancing T-cell responses during an immune response.
• Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
• Immunogen: CD28 antibody was raised in rabbit using residues 72-85 [SQQLQVYSKTGFN] of the Ig-V region of human CD28 as the immunogen.
• Preparation and Storage: Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for anti-CD28 antibody

Affinity purified Rabbit polyclonal CD28 antibody

Product Categories/Family for anti-CD28 antibody

Immunology; Purified Polyclonal Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 5453611
• NCBI GeneID: 940
• NCBI Accession #: NP_006130
• NCBI GenBank Nucleotide #: NM_006139.3
• UniProt Accession #: P10747; Q13964; Q52M23; Q70WG0; Q8NI54; Q8NI55; Q8NI56; Q8WXJ2; Q9BYV0; A8KAC1
• Molecular Weight: 26,186 Da
• NCBI Official Full Name: T-cell-specific surface glycoprotein CD28 isoform 1
• NCBI Official Synonym Full Names: CD28 molecule
• NCBI Official Symbol: CD28
• NCBI Official Synonym Symbols: Tp44
• NCBI Protein Information: T-cell-specific surface glycoprotein CD28
• UniProt Protein Name: T-cell-specific surface glycoprotein CD28
• Protein Family: T-cell-specific surface glycoprotein
• UniProt Gene Name: CD28
• UniProt Entry Name: CD28_HUMAN

NCBI Description

The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

Uniprot Description

CD28: a type I plasma membrane protein Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Binds to B7-1 and -2. Expressed in T cells and plasma cells, but not in less mature B cells. Six splice-variant isoforms have been described.

Protein type: Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 2q33

Cellular Component: integral to plasma membrane; plasma membrane; immunological synapse; cytosol; external side of plasma membrane

Molecular Function: identical protein binding; protein binding; protease binding; SH3/SH2 adaptor activity; coreceptor activity

Biological Process: positive regulation of isotype switching to IgG isotypes; viral reproduction; positive regulation of translation; nerve growth factor receptor signaling pathway; positive regulation of interleukin-2 biosynthetic process; cytokine biosynthetic process; T cell receptor signaling pathway; positive regulation of inflammatory response to antigenic stimulus; cell surface receptor linked signal transduction; positive regulation of T cell proliferation; regulatory T cell differentiation; epidermal growth factor receptor signaling pathway; positive regulation of viral genome replication; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; positive regulation of mitosis; negative thymic T cell selection; regulation of defense response to virus by virus; humoral immune response; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; T cell costimulation; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of alpha-beta T cell proliferation