Testing Data
(Western blot analysis on D3 (A) and PC12 (B) using anti-CD271 polyclonal antibody.)
anti-Mouse, Rat CD271 Polyclonal Antibody | anti-CD271 antibody
CD271 (Tumor necrosis factor receptor superfamily member16) Antibody
Gene Names
Ngfr; p75; LNGFR; p75NTR; p75NGFR; Tnfrsf16
Reactivity
Mouse, Rat
Applications
Western Blot
Purity
Affinity Purified
Synonyms
CD271; Polyclonal Antibody; CD271 (Tumor necrosis factor receptor superfamily member16) Antibody; anti-CD271 antibody
Reactivity
Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to a region of CD271.
Purity/Purification
Affinity Purified
Form/Format
Liquid
Sequence Length
417
Applicable Applications for anti-CD271 antibody
Western Blot (WB)
Application Notes
WB: 1:2,000~1:5,000
Cellular Localization
Cell Membrane
Positive Control
PC12, D3
Preparation and Storage
Store at +4 degree C after thawing. Aliquot store at-20 degree C or-80 degree C. Avoid repeated freeze/thaw cycles.
Testing Data
(Western blot analysis on D3 (A) and PC12 (B) using anti-CD271 polyclonal antibody.)
Testing Data
(Western blot analysis on D3 (A) and PC12 (B) using anti-CD271 polyclonal antibody.)
Related Product Information for anti-CD271 antibody
NGFR p75 or CD271 is a 75kD transmembrane glycoprotein consisting of an extracellular domain which contains four cysteine rich domains responsible for ligand binding, a transmembrane domain, and a cytoplasmic domain. NGFR p75 displays paradoxical functions when acting alone or with other receptor proteins. Working in concert with Trk receptors, it recognizes neurotrophins and transmits trophic signals into the cell. NGFR p75 is necessary for regulating neuronal growth, migration, differentiation and cell death during development of the central and peripheral nervous system.
References
1 . "Low-affinity nerve-growth factor receptor (p75NTR) can serve as a receptor for rabies virus."Tuffereau C., Benejean J., Blondel D., Kieffer B., Flamand A.EMBO J. 17:7250-7259(1998). 2. "Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry."Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M.J. Proteome Res. 7:5314-5326(2008).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
50kDa
NCBI Official Full Name
Tumor necrosis factor receptor superfamily member 16
NCBI Official Synonym Full Names
nerve growth factor receptor (TNFR superfamily, member 16)
NCBI Official Symbol
Ngfr
NCBI Official Synonym Symbols
p75; LNGFR; p75NTR; p75NGFR; Tnfrsf16
NCBI Protein Information
tumor necrosis factor receptor superfamily member 16
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 16
UniProt Gene Name
Ngfr
UniProt Synonym Gene Names
Tnfrsf16; NGF receptor
Uniprot Description
Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells (). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake. Binds to rabies virus glycoprotein Gs. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.
Research Articles on CD271
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Product Notes
The CD271 ngfr (Catalog #AAA857122) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The CD271 (Tumor necrosis factor receptor superfamily member16) Antibody reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CD271 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:2,000~1:5,000. Researchers should empirically determine the suitability of the CD271 ngfr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD271, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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