Rabbit anti-Human, Rat CD169 Polyclonal Antibody | anti-CD169 antibody

CD169 Polyclonal Antibody

Cat. Num. AAA2556181

• Gene Names: SIGLEC1; SN; CD169; SIGLEC-1
• Reactivity: Human, Rat
• Applications: Immunohistochemistry
• Purity: Affinity Purification
• Synonyms: CD169; Polyclonal Antibody; CD169 Polyclonal Antibody; CD169 antigen; dJ1009E24.1; DKFZp667F058; FLJ00051; FLJ00055; FLJ00073; FLJ00411; FLJ32150; Sialic acid binding Ig like lectin 1; sialic acid binding Ig-like lectin 1; sialoadhesin; Sialic acid binding immunoglobulin like lectin 1; Sialic acid-binding Ig-like lectin 1; Sialoadhesin; Siglec 1; Siglec-1; Siglec1; SN; anti-CD169 antibody

• Host: Rabbit
• Reactivity: Human, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Form/Format: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH 7.4
• Sequence Length: 1,649

• Applicable Applications for anti-CD169 antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:200-1:800
• Immunogen: KLH conjugated synthetic peptide corresponding to Mouse CD169
• Note: Centrifuge before opening to ensure complete recovery of vial contents.
• Preparation and Storage: Store at -20°C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human tonsil using CD169 Polyclonal Antibody at dilution of 1:300.)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded rat lymph node using CD169 Polyclonal Antibody at dilution of 1:300.)

Related Product Information for anti-CD169 antibody

This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined.SIGLEC1 (Sialic Acid Binding Ig Like Lectin 1) is a Protein Coding gene. Diseases associated with SIGLEC1 include Proliferative Glomerulonephritis and Diffuse Cutaneous Systemic Sclerosis. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Innate Immune System. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CD22.

Product Categories/Family for anti-CD169 antibody

Cancer; Immunology; Microbiology

NCBI and Uniprot Product Information

• NCBI GI #: 13489095
• NCBI GeneID: 6614
• NCBI Accession #: NP_075556.1
• NCBI GenBank Nucleotide #: NM_023068.4
• UniProt Accession #: Q9BZZ2; Q96DL4; Q9GZS5; Q9H1H6; Q9H1H7; Q9H7L7
• NCBI Official Full Name: sialoadhesin isoform 1
• NCBI Official Synonym Full Names: sialic acid binding Ig like lectin 1
• NCBI Official Symbol: SIGLEC1
• NCBI Official Synonym Symbols: SN; CD169; SIGLEC-1
• NCBI Protein Information: sialoadhesin
• UniProt Protein Name: Sialoadhesin
• UniProt Gene Name: SIGLEC1
• UniProt Synonym Gene Names: SN; Siglec-1

NCBI Description

This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (). Binds to SPN/CD43 on T-cells (). May play a role in hemopoiesis.