Goat anti-Human CD166 Polyclonal Antibody | anti-ALCAM antibody

CD166 (ALCAM, Activated Leukocyte Cell Adhesion Molecule)

Cat. Num. AAA622076

• Gene Names: ALCAM; MEMD; CD166; FLJ38514; MGC71733
• Reactivity: Human
• Applications: Western Blot, Neutralization Assay
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: CD166; Polyclonal Antibody; CD166 (ALCAM; Activated Leukocyte Cell Adhesion Molecule); Anti -CD166 (ALCAM; anti-ALCAM antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human ALCAM.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a lyophilized powder in 0.2um sterile-filtered solution in PBS with 5% trehalose. Reconstitute with 40-50% glycerol, PBS.

• Applicable Applications for anti-ALCAM antibody: Western Blot (WB), Neutralization
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: ELISA: 0.5-1.0ug/ml; Western Blot: 0.1-0.2ug/ml
• Immunogen: NS0-derived rhALCAM extracellular domain.
• Preparation and Storage: Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-ALCAM antibody

Human CD166 is a type 1 glycoprotein expressed on activated T cells, B cells and monocytes and appears to be the ligand for CD6 (1,2). Human CD166 may be important for activation of T cells.

Product Categories/Family for anti-ALCAM antibody

Antibodies; Abs to CD Markers

NCBI and Uniprot Product Information

• NCBI GI #: 68163411
• NCBI GeneID: 214
• NCBI Accession #: NP_001618.2
• NCBI GenBank Nucleotide #: NM_001627.3
• UniProt Accession #: Q13740; O60892; Q1HGM8; Q1HGM9; B2RNS3; Q6PEY4; Q6ZS95
• Molecular Weight: 65,102 Da
• NCBI Official Full Name: CD166 antigen
• NCBI Official Synonym Full Names: activated leukocyte cell adhesion molecule
• NCBI Official Symbol: ALCAM
• NCBI Official Synonym Symbols: MEMD; CD166; FLJ38514; MGC71733
• NCBI Protein Information: CD166 antigen; OTTHUMP00000214313; OTTHUMP00000214314; OTTHUMP00000214315; activated leucocyte cell adhesion molecule
• UniProt Protein Name: CD166 antigen
• Protein Family: CD166 antigen
• UniProt Gene Name: ALCAM
• UniProt Synonym Gene Names: MEMD
• UniProt Entry Name: CD166_HUMAN

NCBI Description

This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2011]

Uniprot Description

ALCAM: Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q13.1

Cellular Component: focal adhesion; cell soma; axon; integral to membrane; external side of plasma membrane

Molecular Function: protein binding; receptor binding

Biological Process: axon guidance; motor axon guidance; cell adhesion; signal transduction