Western Blot (WB)
(Anti-CD134/OX40 antibody, MBS176055, Western blottingLane 1: U87 Cell LysateLane 2: HELA Cell LysateLane 3: HT1080 Cell LysateLane 4: JURKAT Cell LysateLane 5: COLO320 Cell LysateLane 6: MCF-7 Cell LysateLane 7: SHC Cell LysateLane 8: COLO320 Cell LysateLane 9: SGC Cell Lysate)
Rabbit anti-Human CD134/OX40 Polyclonal Antibody | anti-TNFRSF4 antibody
Anti-CD134/OX40 antibody
Western Blot (WB)
(Anti-CD134/OX40 antibody, MBS176055, Western blottingLane 1: U87 Cell LysateLane 2: HELA Cell LysateLane 3: HT1080 Cell LysateLane 4: JURKAT Cell LysateLane 5: COLO320 Cell LysateLane 6: MCF-7 Cell LysateLane 7: SHC Cell LysateLane 8: COLO320 Cell LysateLane 9: SGC Cell Lysate)
Western Blot (WB)
(Anti-CD134/OX40 antibody, MBS176055, Western blottingLane 1: U87 Cell LysateLane 2: HELA Cell LysateLane 3: HT1080 Cell LysateLane 4: JURKAT Cell LysateLane 5: COLO320 Cell LysateLane 6: MCF-7 Cell LysateLane 7: SHC Cell LysateLane 8: COLO320 Cell LysateLane 9: SGC Cell Lysate)
Background: Tumor necrosis factor receptor superfamily, member4, also known as ACT35 or CD134 is a cell surface glycoprotein that was discovered through the production of a monoclonal antibody raised against the HUT-102 cell line. It belongs to the tumor necrosis factor receptor superfamily. CD134 was mapped to 1p36 by fluorescence in situ hybridization. CD134 is the primary receptor for feline immunodeficiency virus. CD134 expression can promote viral binding and renders cells permissive for viral entry, productive infection, and syncytium formation. Stimulating the receptor can improve the response to a powerful virus vector and may be useful in vaccine development.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
Uniprot Description
TNFRSF4: Receptor for TNFSF4/OX40L/GP34.
Protein type: Apoptosis; Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p36
Cellular Component: cell surface; integral to plasma membrane; external side of plasma membrane
Molecular Function: tumor necrosis factor receptor activity
Biological Process: regulation of apoptosis; T cell proliferation; tumor necrosis factor-mediated signaling pathway; negative regulation of transcription factor activity; negative regulation of cytokine secretion; positive regulation of B cell proliferation; cellular defense response; immune response; positive regulation of immunoglobulin secretion; inflammatory response; regulation of protein kinase activity; negative regulation of transcription, DNA-dependent
Disease: Immunodeficiency 16
Research Articles on TNFRSF4
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Product Notes
The TNFRSF4 tnfrsf4 (Catalog #AAA176055) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-CD134/OX40 antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD134/OX40 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the TNFRSF4 tnfrsf4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD134/OX40, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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