Western Blot
(Western blot analysis on D3 using anti CD105 polyclonal antibody.)
anti-Mouse CD105 Polyclonal Antibody | anti-CD105 antibody
CD105 (Endoglin) Antibody
Gene Names
Eng; Endo; CD105; AI528660; AI662476; S-endoglin
Reactivity
Mouse
Applications
Western Blot
Purity
Affinity purified
Synonyms
CD105; Polyclonal Antibody; CD105 (Endoglin) Antibody; anti-CD105 antibody
Reactivity
Mouse
Clonality
Polyclonal
Isotype
IgG
Specificity
This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to mouse CD105.
Purity/Purification
Affinity purified
Form/Format
1*TBS (pH7.4), 0.5%BSA, 25% Glycerol.
Sequence Length
653
Applicable Applications for anti-CD105 antibody
Western Blot (WB)
Application Notes
WB: 1:500
Preservative
0.05% Sodium Azide.
Cellular Localization
Cell Membrane
Positive Control
D3
Preparation and Storage
Store at +4 degree C after thawing. Aliquot store at-20 degree C or-80 degree C. Avoid repeated freeze/thaw cycles.
Western Blot
(Western blot analysis on D3 using anti CD105 polyclonal antibody.)
Western Blot
(Western blot analysis on D3 using anti CD105 polyclonal antibody.)
Related Product Information for anti-CD105 antibody
Endoglin is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex. The protein consists of a homodimer of 180 kDA with disulfide links. It has been found on endothelial cells, activated macrophages, fibroblasts, and smooth muscle cells. Endoglin has been found to be part of the TGF-beta1 receptor complex. It thus may be involved in the binding of TGF-beta1, TGF-beta3, activin-A, BMP-2, and BMP-7. In humans endoglin may be involved in the autosomal dominant disorder known as hereditary hemorrhagic telangiectasia type 1. This condition leads to frequent nose bleeds, telangiectases on skin and mucosa and may cause arteriovenous malformations in different organs including brain, lung, and liver.
References
1. "Cloning and expression of a cDNA encoding mouse endoglin, an endothelial cell TGF-beta ligand."Ge A.Z., Butcher E.C.Gene 138:201-206(1994). "Molecular characterization and in situ localization of murine endoglin reveal that it is a transforming growth factor-beta binding protein of endothelial and stromal cells."St Jacques S., Cymerman U., Pece N., Letarte M.Endocrinology 134:2645-2657(1994).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
74kDa
NCBI Official Full Name
endoglin isoform 1
NCBI Official Synonym Full Names
endoglin
NCBI Official Symbol
Eng
NCBI Official Synonym Symbols
Endo; CD105; AI528660; AI662476; S-endoglin
NCBI Protein Information
endoglin
UniProt Protein Name
Endoglin
UniProt Gene Name
Eng
UniProt Synonym Gene Names
Edg
Uniprot Description
Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:10625534). Required for normal structure and integrity of adult vasculature (). Regulates the migration of vascular endothelial cells (PubMed:17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (PubMed:10625534). May play a role in the binding of endothelial cells to integrins. Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:23300529). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 ().
Research Articles on CD105
Similar Products
Product Notes
The CD105 eng (Catalog #AAA857479) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The CD105 (Endoglin) Antibody reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CD105 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500. Researchers should empirically determine the suitability of the CD105 eng for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD105, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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