Western Blot (WB)
(Anti-CCR4 antibody, MBS175150, Western blottingAll lanes: Anti CCR4 (MBS175150) at 0.5ug/mlLane 1: Rat Thymus Tissue Lysate at 50ugLane 2: Rat Spleen Tissue Lysate at 50ugLane 3: HEPA Whole Cell Lysate at 40ugPredicted bind size: 41KDObserved bind size: 41KD )
Rabbit anti-Mouse, Rat CCR4 Polyclonal Antibody | anti-CCR4 antibody
Anti-CCR4 antibody
Western Blot (WB)
(Anti-CCR4 antibody, MBS175150, Western blottingAll lanes: Anti CCR4 (MBS175150) at 0.5ug/mlLane 1: Rat Thymus Tissue Lysate at 50ugLane 2: Rat Spleen Tissue Lysate at 50ugLane 3: HEPA Whole Cell Lysate at 40ugPredicted bind size: 41KDObserved bind size: 41KD )
Western Blot (WB)
(Anti-CCR4 antibody, MBS175150, Western blottingAll lanes: Anti CCR4 (MBS175150) at 0.5ug/mlLane 1: Rat Thymus Tissue Lysate at 50ugLane 2: Rat Spleen Tissue Lysate at 50ugLane 3: HEPA Whole Cell Lysate at 40ugPredicted bind size: 41KDObserved bind size: 41KD )
Background: CCR4,C-C chemokine receptor type 4 is a protein that in humans is encoded by the CCR4 gene. CCR4 has also recently been designated CD194(cluster of differentiation 194). The protein encoded by this gene belongs to the G protein-coupled receptor family. It is a receptor for the following CC chemokines. The CCR4 gene is mapped to chromosome 3. Chemokines are a group of small structurally related proteins that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.
NCBI and Uniprot Product Information
Uniprot Description
CCR4: High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol- calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. Belongs to the G-protein coupled receptor 1 family.
Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral; Motility/polarity/chemotaxis
Cellular Component: cell soma; membrane; plasma membrane; integral to membrane; external side of plasma membrane
Molecular Function: G-protein coupled receptor activity; signal transducer activity; C-C chemokine receptor activity; chemokine receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of positive chemotaxis; neuron migration; immune response; signal transduction; chemotaxis; inflammatory response; tolerance induction
Research Articles on CCR4
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Product Notes
The CCR4 ccr4 (Catalog #AAA175150) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-CCR4 antibody reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CCR4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the CCR4 ccr4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CCR4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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