Rabbit anti-Human CCR1 Polyclonal Antibody | anti-CCR1 antibody

CCR1, NT (CCR1, CMKBR1, CMKR1, SCYAR1, C-C chemokine receptor type 1, HM145, LD78 receptor, Macrophage inflammatory protein 1-alpha receptor, RANTES-R, CD191)

Cat. Num. AAA646533

• Gene Names: CCR1; CKR1; CD191; CKR-1; HM145; CMKBR1; MIP1aR; SCYAR1
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry, Flow Cytometry, Functional Assay
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: CCR1; Polyclonal Antibody; NT (CCR1; CMKBR1; CMKR1; SCYAR1; C-C chemokine receptor type 1; HM145; LD78 receptor; Macrophage inflammatory protein 1-alpha receptor; RANTES-R; CD191); Anti -CCR1; anti-CCR1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-CCR1 antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
• Application Notes: Suitable for use in Western Blot, Immunohistochemistry, Flow Cytometry, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500; Immunohistochemistry: 1:50-100; Flow Cytometry: 1:10-50
• Immunogen: CCR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2~31 amino acids from the N-terminal region of human CCR1.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of CCR1 Antibody (N-term) in 293 cell line lysates (35ug/lane). CCR1 (arrow) was detected using the purified Pab.)

Immunohistochemistry (IHC)

(CCR1 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CCR1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Flow Cytometry (FC/FACS)

(CCR1 Antibody (N-term) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)

Related Product Information for anti-CCR1 antibody

CCR1 encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p.

Product Categories/Family for anti-CCR1 antibody

Antibodies; Abs to CD Markers

NCBI and Uniprot Product Information

• NCBI GI #: 4502631
• NCBI GeneID: 1230
• NCBI Accession #: NP_001286.1
• NCBI GenBank Nucleotide #: NM_001295.2
• UniProt Accession #: P32246; Q86VA9
• Molecular Weight: 41,173 Da
• NCBI Official Full Name: C-C chemokine receptor type 1
• NCBI Official Synonym Full Names: chemokine (C-C motif) receptor 1
• NCBI Official Symbol: CCR1
• NCBI Official Synonym Symbols: CKR1; CD191; CKR-1; HM145; CMKBR1; MIP1aR; SCYAR1
• NCBI Protein Information: C-C chemokine receptor type 1; CCR-1; CC-CKR-1; RANTES-R; C-C CKR-1; MIP-1alpha-R; LD78 receptor; RANTES receptor; macrophage inflammatory protein 1-alpha receptor
• UniProt Protein Name: C-C chemokine receptor type 1
• Protein Family: C-C chemokine receptor
• UniProt Gene Name: CCR1
• UniProt Synonym Gene Names: CMKBR1; CMKR1; SCYAR1; C-C CKR-1; CC-CKR-1; CCR-1; CCR1
• UniProt Entry Name: CCR1_HUMAN

NCBI Description

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.

Subunit structure: Interacts with CREB3. Ref.5

Subcellular location: Cell membrane; Multi-pass membrane protein Ref.6.

Tissue specificity: Widely expressed in different hematopoietic cells.

Induction: Up-regulated by CREB3. Ref.6

Sequence similarities: Belongs to the G-protein coupled receptor 1 family.