Goat anti-Human CCR1 Polyclonal Antibody | anti-CCR1 antibody

CCR1, NT (CCR1, CMKBR1, SCYAR1, C-C chemokine receptor type 1, HM145, Macrophage inflammatory protein 1-alpha receptor, CD191)

Cat. Num. AAA641829

• Gene Names: CCR1; CKR1; CD191; CKR-1; HM145; CMKBR1; MIP1aR; SCYAR1
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: CCR1; Polyclonal Antibody; NT (CCR1; CMKBR1; SCYAR1; C-C chemokine receptor type 1; HM145; Macrophage inflammatory protein 1-alpha receptor; CD191); Anti -CCR1; anti-CCR1 antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human CCR1.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS,1mg/ml BSA, 0.1% sodium azide.

• Applicable Applications for anti-CCR1 antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
• Application Notes: Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry.; Dilution: ELISA: 1:100,000; Western Blot: 1:1000; Immunohistochemistry (Paraffin): 5ug/ml; Immunocytochemistry: 1:400
• Immunogen: Synthetic peptide corresponding to TEDYDTTTEFDYGDATPC, aa7-24 from human CCR1 at N-Teminal.
• Preparation and Storage: May be stored at 20 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -70 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(CCR1 IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced retrieval.)

Related Product Information for anti-CCR1 antibody

CCR1, a Chemokine Receptor, affects stem cell proliferation and mediates systemic inflammatory responses. This receptor is stimulated by the beta chemokines RANTES, MCP-1, and MIP-1 alpha. Disruption of CCR1 enhances protection from pulmonary inflammation and reduces the development of respiratory distress syndrome in rat.

Product Categories/Family for anti-CCR1 antibody

Antibodies; Abs to CD Markers

NCBI and Uniprot Product Information

• NCBI GI #: 4502631
• NCBI GeneID: 1230
• NCBI Accession #: NP_001286.1
• NCBI GenBank Nucleotide #: NM_001295.2
• UniProt Accession #: P32246; Q86VA9
• Molecular Weight: 41,173 Da
• NCBI Official Full Name: C-C chemokine receptor type 1
• NCBI Official Synonym Full Names: chemokine (C-C motif) receptor 1
• NCBI Official Symbol: CCR1
• NCBI Official Synonym Symbols: CKR1; CD191; CKR-1; HM145; CMKBR1; MIP1aR; SCYAR1
• NCBI Protein Information: C-C chemokine receptor type 1; CCR-1; CC-CKR-1; RANTES-R; C-C CKR-1; MIP-1alpha-R; LD78 receptor; RANTES receptor; macrophage inflammatory protein 1-alpha receptor
• UniProt Protein Name: C-C chemokine receptor type 1
• Protein Family: C-C chemokine receptor
• UniProt Gene Name: CCR1
• UniProt Synonym Gene Names: CMKBR1; CMKR1; SCYAR1; C-C CKR-1; CC-CKR-1; CCR-1; CCR1
• UniProt Entry Name: CCR1_HUMAN

NCBI Description

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]

Uniprot Description

CCR1: Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1- beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; GPCR, family 1; Motility/polarity/chemotaxis; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3p21

Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane

Molecular Function: protein binding; C-C chemokine receptor activity; chemokine receptor activity; C-C chemokine binding; phosphoinositide phospholipase C activity

Biological Process: exocytosis; metabolic process; positive regulation of osteoclast differentiation; cytokine and chemokine mediated signaling pathway; chemotaxis; cellular calcium ion homeostasis; negative regulation of bone mineralization; G-protein signaling, coupled to cyclic nucleotide second messenger; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; cell-cell signaling; calcium ion transport; response to wounding; dendritic cell chemotaxis; immune response; inflammatory response; cell adhesion; positive regulation of calcium ion transport