Goat anti-Human CCR D6 Polyclonal Antibody | anti-ACKR2 antibody

CCR D6 (Chemokine Receptor D6, beta)

Cat. Num. AAA614363

• Gene Names: ACKR2; D6; hD6; CCR9; CCBP2; CCR10; CMKBR9
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry, Flow Cytometry, Functional Assay
• Purity: Affinity Purified; Affinity purified.
• Synonyms: CCR D6; Polyclonal Antibody; CCR D6 (Chemokine Receptor D6; beta); Anti -CCR D6 (Chemokine Receptor D6; anti-ACKR2 antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Peptide sequence is < 50% identical to other chemokine receptors in this region. Cross reactivity to mouse CCR9 not tested. Crossreacts with human.
• Purity/Purification: Affinity Purified; Affinity purified.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 1mg/ml BSA, 0.1% sodium azide.

• Applicable Applications for anti-ACKR2 antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
• Application Notes: ELISA: 1:100,000; Western Blotting: 1:1,000; Immunohistochemistry: 1:250; Flow Cytometry: 1-3ul/10e6 cells/50-100ul
• Immunogen: Synthetic peptide CLATEDADSENSSFYYYDYLDEVAFML corresponding to the N-terminal extracellular domain of human CCR D6.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-ACKR2 antibody

Chemokine receptors are specialized proteins that function at the surface of cells, and enable chemokines to trigger internal cellular processes. Chemokines and their receptors play a pivotal role in lymphocyte trafficking, recruiting and recirculation. Chemokines act through seven transmembrane G protein-coupled receptors. The chemokine system is increasingly recognized to play an important role in lymphocyte biology.

Product Categories/Family for anti-ACKR2 antibody

Antibodies; Abs to G Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 13929467
• NCBI GeneID: 1238
• NCBI Accession #: NP_001287.2
• NCBI GenBank Nucleotide #: NM_001296.4
• UniProt Accession #: O00590; O00537; Q53YA1; Q86UN9; Q96A02; B2R8Y8
• Molecular Weight: 43,443 Da
• NCBI Official Full Name: chemokine-binding protein 2
• NCBI Official Synonym Full Names: atypical chemokine receptor 2
• NCBI Official Symbol: ACKR2
• NCBI Official Synonym Symbols: D6; hD6; CCR9; CCBP2; CCR10; CMKBR9
• NCBI Protein Information: chemokine-binding protein 2; chemokine receptor D6; chemokine receptor CCR-9; C-C chemokine receptor D6; chemokine receptor CCR-10; chemokine (C-C) receptor 9; chemokine binding protein 2; chemokine-binding protein D6; chemokine (C-C motif) receptor 9; CC-chemokine-binding receptor JAB61
• UniProt Protein Name: Chemokine-binding protein 2
• Protein Family: Atypical chemokine receptor
• UniProt Gene Name: CCBP2
• UniProt Synonym Gene Names: CCR10; CMKBR9
• UniProt Entry Name: CCBP2_HUMAN

NCBI Description

This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008]

Uniprot Description

CCBP2: Receptor for C-C type chemokines including SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: recycling endosome; integral to plasma membrane; early endosome; plasma membrane; actin filament

Molecular Function: C-C chemokine receptor activity; chemokine receptor activity; C-C chemokine binding; scavenger receptor activity; C-X-C chemokine receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; receptor-mediated endocytosis; neutrophil activation; multicellular organismal development; immune response; chemotaxis; inflammatory response