Rabbit ACKR2 / CCR10 / D6 Polyclonal Antibody | anti-ACKR2 antibody

Rabbit Polyclonal to Human ACKR2 / CCR10 / D6

Cat. Num. AAA247554

• Gene Names: ACKR2; D6; hD6; CCR9; CCBP2; CCR10; CMKBR9
• Reactivity: Human; Predicted Reactivity: Gorilla (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: ACKR2 / CCR10 / D6; Polyclonal Antibody; Rabbit Polyclonal to Human ACKR2 / CCR10 / D6; Anti-ACKR2 / CCR10 / D6 Antibody (N-Terminus) IHC-plus; ACKR2; C-C chemokine receptor D6; CCBP2; Chemokine (C-C) receptor 9; Chemokine binding protein 2; C-C chemokine receptor 10; Chemokine-binding protein 2; CMKBR9; Chemokine receptor CCR-9; G protein coupled receptor d6; HD6; Human ACKR2; CCR10; D6; anti-ACKR2 antibody

• Host: Rabbit
• Reactivity: Human; Predicted Reactivity: Gorilla (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human CCBP2 / D6. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 384

• Applicable Applications for anti-ACKR2 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (20 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 18 amino acid peptide from N-terminal extracellular domain of human CCBP2 / D6. Percent identity with other species by BLAST analysis: Human (100%); Gorilla (94%); Gibbon, Marmoset (83%).
• Immunogen Type: Synthetic peptide
• Immunogen: ACKR2 / CCR10 / D6 antibody was raised against synthetic 18 amino acid peptide from N-terminal extracellular domain of human CCBP2 / D6. Percent identity with other species by BLAST analysis: Human (100%); Gorilla (94%); Gibbon, Marmoset (83%).
• Antigen Modification: N-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-CCBP2 / D6 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-ACKR2 antibody

Human Chemokine Receptor D6 is activated by beta chemokines (CC motif) such as Monocyte chemoattractant protein (MCP), mucosae-associated epithelial chemokine (MEC) and keratinocyte-expressed cutaneous T cell-attracting chemokine (CTACK; CCL27). Two alternatively spliced variants have been isolated.

Product Categories/Family for anti-ACKR2 antibody

Family: GPCR; Subfamily: Chemokine

NCBI and Uniprot Product Information

• NCBI GI #: 13929467
• NCBI GeneID: 1238
• NCBI Accession #: NP_001287.2
• NCBI GenBank Nucleotide #: NM_001296.4
• UniProt Accession #: O00590; O00537; Q53YA1; Q86UN9; Q96A02; B2R8Y8
• Molecular Weight: 43,443 Da
• NCBI Official Full Name: atypical chemokine receptor 2
• NCBI Official Synonym Full Names: atypical chemokine receptor 2
• NCBI Official Symbol: ACKR2
• NCBI Official Synonym Symbols: D6; hD6; CCR9; CCBP2; CCR10; CMKBR9
• NCBI Protein Information: atypical chemokine receptor 2; chemokine receptor D6; chemokine receptor CCR-9; C-C chemokine receptor D6; chemokine receptor CCR-10; chemokine (C-C) receptor 9; chemokine binding protein 2; chemokine-binding protein 2; chemokine-binding protein D6; chemokine (C-C motif) receptor 9; CC-chemokine-binding receptor JAB61
• UniProt Protein Name: Atypical chemokine receptor 2
• Protein Family: Atypical chemokine receptor
• UniProt Gene Name: ACKR2
• UniProt Synonym Gene Names: CCBP2; CCR10; CMKBR9; D6
• UniProt Entry Name: ACKR2_HUMAN

NCBI Description

This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008]

Uniprot Description

CCBP2: Receptor for C-C type chemokines including SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: recycling endosome; integral to plasma membrane; early endosome; plasma membrane; actin filament

Molecular Function: C-C chemokine receptor activity; chemokine receptor activity; C-C chemokine binding; scavenger receptor activity; C-X-C chemokine receptor activity

Biological Process: receptor-mediated endocytosis; G-protein coupled receptor protein signaling pathway; neutrophil activation; multicellular organismal development; immune response; inflammatory response; chemotaxis